Showing papers by "Edamana Prasad published in 2021"

5FU encapsulated polyglycerol sebacate nanoparticles as anti-cancer drug carriers

Abstract: The majority of anti-cancer drugs fail to reach clinical trials due to their low water solubility. A biocompatible drug delivery system that encapsulates and efficiently delivers hydrophobic drugs to the target site is the need of the hour. This study addresses the issue by focusing on a polymeric polyglycerol sebacate (PGS) nanoparticles loaded with 5-fluorouracil (5FU), a primary line chemotherapy drug for many types of cancers. The generated nanoparticle (PGS-NP) was biocompatible and had minimal cytotoxicity against the MDA-MB-231 and A549 cell lines, even at a high concentration of 100 μg mL−1. The cell viability post treatment with PGS nanoparticles encapsulated with 5FU (PGS-5FU) decreased to as low as around 40% whereas, in the case of treatment with 5FU, the viability percentage increased. The nanoparticles also showed controlled drug release when encapsulated with 5FU. This striking observation suggested that these nanoparticles can improve the efficacy of drug delivery to tumor sites. Apoptosis assay and caspase-3 activity quantification supported these data wherein PGS-5FU treatment showed almost three times caspase-3 activity as compared to control cells. Additionally, throughout all the experiments, MDA-MB-231 cells were more sensitive to PGS-5FU than A549 cells, indicating that these nanoparticles are ideal for breast cancer treatment. In summary, 5FU encapsulated PGS nanoparticles are a potential drug carrier to deliver 5FU efficiently to cancer cells.

Conducting and superhydrophobic hybrid 2D material from coronene and pyrene

Abstract: Graphdiyne, a recent addition to the family of 2D covalent organic nanosheet structures, is known for its structural stability and potential applications in catalysis, sensors, electronics and optoelectronics. The design and synthesis of graphdiyne analogues with well-defined structures and useful applications remains a challenging task for materials chemists. Herein, we report a novel, well-defined 2D nanosheet from a coronene–pyrene hybrid 2D material (COPY), with extended π conjugation through acetylenic linkages. The bulk synthesis of the polymeric network has been realized via Sonogashira coupling of 1,4,7,10-tetrabromocoronene and 1,3,6,8-tetraethynylpyrene. The nanosheet is characterized using HR-SEM, TEM, AFM, FT-IR, Raman, XRD and XPS techniques. Electrostatic potential mapping of COPY reveals complete π electron delocalization over the 2D framework with a relatively high electro-negative potential at the acetylenic linkages. Computational study reveals the high planarity of the structure as a result of Cs point group symmetry and the material has a tunable bandgap with respect to the number of coronene and pyrene rings. Extended conjugation in the material accounts for the significant electrical conductivity (1.16 × 10−3 S m−1) that is one order of magnitude higher than that of graphdiyne and comparable to the previously reported pyrediyne (a graphdiyne analogue). The large surface area and porous nature of the material were utilized for oil–water separation by incorporating melamine sponge and cotton fabric. The COPY-incorporated cotton fabric exhibited an oil–water separation efficiency of 95.5%. More importantly, the COPY in the melamine sponge exhibited superhydrophobicity with a contact angle of 154.4°. The oil–water separation efficiency, significant electrical conductivity and superhydrophobicity of the material suggest that COPY can be a valuable candidate in the field of water repellency, anti-corrosion and biosensing.