Edgardo D'Angelo

TL;DR: The effects of inspiratory flow rate and inflation volume on the resistive properties of the total respiratory system were investigated in 16 anesthetized paralyzed humans by using the technique of rapid airway occlusion during constant flow inflation to measure the intrinsic resistance and effective additional resistance as the result of viscoelastic pressure dissipations within the pulmonary and chest wall tissues.

TL;DR: Pulmonary and chest wall mechanics were studied in 18 anesthetized paralyzed supine humans by use of the technique of rapid airway occlusion during constant-flow inflation and found that Static and dynamic elastances, as well as delta R, were higher for the lung than for the chest wall.

TL;DR: Extended MV on ZEEP induces histological evidence of peripheral airway injury with a concurrent increase in Rint, which persists after restoration of normal end-expiratory volumes, which is probably due to cyclic opening and closing of peripheralAirways on ZEP.

TL;DR: In patients with tidal airway closure (CV > EELV), there is not only impairment of pulmonary gas exchange, but also peripheral airway disease due to injury of the peripheral airways, and assessment of the “open volume”, as opposed to the ‘closing volume’, is proposed because it is easier to perform and it requires less equipment.

TL;DR: Thirteen normal subjects, sitting in a body plethysmograph and breathing through a pneumotachograph, performed forced vital capacity maneuvers after a rapid inspiration without or with an end-inspiratory pause (maneuvers 1 and 2), the pause lasting 4-6 s.