Edina A. Wappler-Guzzetta

TL;DR: Given the growing clinical importance of anti-M deliriant hallucinogens, the use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions are discussed.

TL;DR: The importance of arecoline is supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine) and social and historical aspects of its use and abuse.

TL;DR: In this paper, the authors discuss mechanisms of zebrafish aggression and their pharmacological, pharmacogenetic and pharmacogenomic models, as well as recent developments and existing challenges in this field.

TL;DR: How DM alters brain functions and behavior in zebrafish is discussed, and their translational relevance to studying DM-related CNS pathogenesis in humans is summarized.

TL;DR: Dividing the core symptoms into easily translatable, evolutionarily conserved phenotypes is an effective way to reevaluate current depression modeling, and novel approaches based on the endophenotype paradigm, cross-species trait genetics and ‘domain interplay concept’ will enhance experimental modeling of depression and antidepressant drug discovery.