E
Edmond J. LaVoie
Researcher at Rutgers University
Publications - 182
Citations - 8160
Edmond J. LaVoie is an academic researcher from Rutgers University. The author has contributed to research in topics: Topoisomerase & Cytotoxicity. The author has an hindex of 42, co-authored 178 publications receiving 7619 citations. Previous affiliations of Edmond J. LaVoie include San Antonio River Authority & National Pingtung University of Science and Technology.
Papers
More filters
Journal ArticleDOI
Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons
TL;DR: Structural-activity studies indicate that the structural rigidity associated with the coralyne ring system may be critical for pharmacological activity, and the presence of a 3,4-methylenedioxy substituent on these coralyn analogues was generally associated with enhanced activity as a topoisomerase poison.
Journal Article
Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer Drug
Tsai-Kun Li,Peter J. Houghton,Shyamal D. Desai,Parima Daroui,Angela A. Liu,Eszter S. Hars,Alexander L. Ruchelman,Edmond J. LaVoie,Leroy F. Liu +8 more
TL;DR: It is shown that ARC-111 is highly potent in scid mice carrying human tumor xenografts and cytotoxicity was reduced in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells, suggesting that the cytotoxic target of ARC- 111 is TOP1.
Journal ArticleDOI
Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors
TL;DR: Several terbenzimidazoles exhibited similar cytotoxicity against variants of human tumor cells that either overexpress MDR1 or are camptothecin-resistant.
Journal ArticleDOI
Antioxidative phenolic glycosides from sage (Salvia officinalis).
TL;DR: An investigation of Salvia officinalis L. has led to the isolation of three new phenolic glycosides, 6-O-caffeoyl-beta-D-fructofuranosyl-(2-->1)-alpha- D-glucopyranosid e, which were found to be moderately active as antioxidants in the DPPH test and metmyoglobin test.
Journal ArticleDOI
Bioisosterism: A Rational Approach in Drug Design
George Patani,Edmond J. LaVoie +1 more
TL;DR: Patani et al. as mentioned in this paper reviewed the use of bioisosteric replacements in drug design and provided an overview of the bioisosteres that incorporates sufficient detail to enable the reader to understand the concepts being delineated.