E
Eduardo Rodriguez
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 21
Citations - 1489
Eduardo Rodriguez is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Germ cell tumors & Chromosome 12. The author has an hindex of 17, co-authored 21 publications receiving 1462 citations. Previous affiliations of Eduardo Rodriguez include Kettering University.
Papers
More filters
Journal Article
Cytogenetic analysis of 124 prospectively ascertained male germ cell tumors.
Eduardo Rodriguez,Susan Mathew,Victor E. Reuter,David H. Ilson,George J. Bosl,R. S. K. Chaganti +5 more
TL;DR: Cytological evidence of gene amplification in the form of homogeneously staining regions and/or double minutes was detected in 24% of extragonadal lesions, suggesting amplification of a gene(s) associated with metastatic progression of these tumors.
Journal ArticleDOI
Isochromosome of Chromosome 12: Clinically Useful Marker for Male Germ Cell Tumors
George J. Bosl,Ethan Dmitrovsky,Victor E. Reuter,Felipe Samaniego,Eduardo Rodriguez,Nancy L. Geller,R. S. K. Chaganti +6 more
TL;DR: The high frequency of i(12p) in series of studies and in those of others indicates that it probably occurs as a very early defect in the development of these tumors, and further studies of chromosome 12 in males with these tumors are warranted.
Journal ArticleDOI
Cytogenetic and molecular analysis of human male germ cell tumors: chromosome 12 abnormalities and gene amplification.
Felipe Samaniego,Eduardo Rodriguez,Jane Houldsworth,Vundavalli V. Murty,Marc Ladanyi,Kusum P. Lele,Quanguang Chen,Ethan Dmitrovsky,Nancy L. Geller,Victor E. Reuter,Suresh C. Jhanwar,George J. Bosl,R. S. K. Chaganti +12 more
TL;DR: It is established that i(12p) is a highly nonrandom chromosome marker of all histologic as well as anatomic presentations of GCTs, and for the first time, cytological evidence of gene amplification in the form of homogeneously staining regions (HSRs) and double minute chromosomes (dmins) is detected.
Journal ArticleDOI
Molecular cytogenetic analysis of i(12p)-negative human male germ cell tumors.
Eduardo Rodriguez,Jane Houldsworth,Victor E. Reuter,Paul S. Meltzer,Ji Zhang,Jeffrey M. Trent,George J. Bosl,R. S. K. Chaganti +7 more
TL;DR: Both i(12p)‐negative and ‐positive groups are characterized by an increased copy number of 12p, which is consistent with a lack of significant clinical or biological difference between them.
Journal ArticleDOI
Origin of adult male mediastinal germ-cell tumours
TL;DR: Gonadal origin of all germ-cell tumours with occasional migration of precursors early in development to extragonadal sites to become established as primary extragonal germ- cell tumours in males is suggested.