Quanguang Chen

TL;DR: The loss of alleles from chromosome 17p and 18 and an increased dosage of gene or genes on chromosomes 5q and 7 as seen in high-stage tumors of various histological subtypes may be associated with progression of disease.

TL;DR: It is established that i(12p) is a highly nonrandom chromosome marker of all histologic as well as anatomic presentations of GCTs, and for the first time, cytological evidence of gene amplification in the form of homogeneously staining regions (HSRs) and double minute chromosomes (dmins) is detected.

TL;DR: This study suggests that the germline mutation in one of the copies accompanied by loss or inactivation of the second copy of the NF1 gene and tumor suppressor gene(s) on 17p and 22q may be associated with the neoplastic transformation; abnormalities of other chromosomes may be related to progression of MPNST.

TL;DR: In this article, clinical, cytogenetic, histopathologic, and immunohistochemical data were obtained in a series of 11 small round cell tumors (SRCT) of bone and soft tissue with the translocation t(11;22) (q24;q12).

TL;DR: These new cell lines were sensitive to taxol and relatively resistant to methotrexate, vinblastine and 5‐fluorouracil when compared with the fibrosarcoma cell line HT‐1080, and should provide a useful model for the study of soft tissue sarcomas and for evaluating new drugs or treatments.