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Ethan Dmitrovsky
Researcher at Dartmouth College
Publications - 158
Citations - 16194
Ethan Dmitrovsky is an academic researcher from Dartmouth College. The author has contributed to research in topics: Retinoic acid & Lung cancer. The author has an hindex of 54, co-authored 154 publications receiving 15717 citations. Previous affiliations of Ethan Dmitrovsky include University of Texas Health Science Center at Houston & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation
Pablo Tamayo,Donna K. Slonim,Jill P. Mesirov,Qing Zhu,Sutisak Kitareewan,Ethan Dmitrovsky,Eric S. Lander,Todd R. Golub,Todd R. Golub +8 more
TL;DR: In this article, the application of self-organizing maps, a type of mathematical cluster analysis that is particularly well suited for recognizing and classifying features in complex, multidi-mensional data, is described.
Journal ArticleDOI
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
Lorenzo F. Sempere,Sarah J. Freemantle,Ian Pitha-Rowe,Eric G. Moss,Ethan Dmitrovsky,Ethan Dmitrovsky,Victor R. Ambros +6 more
TL;DR: The identification of a subset of brain-expressedMiRNAs whose expression behavior is conserved in both mouse and human differentiating neurons implicates these miRNAs in mammalian neuronal development or function.
Journal ArticleDOI
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).
Raymond P. Warrell,Stanley R. Frankel,Wilson H. Miller,David A. Scheinberg,Loretta M. Itri,Walter N. Hittelman,Rohini Vyas,Michael Andreeff,Agostino Tafuri,Ann A. Jakubowski,Janice Gabrilove,Michael Gordon,Ethan Dmitrovsky +12 more
TL;DR: Tretinoin is a safe and highly effective agent for inducing complete remission in patients with acute promyelocytic leukemia and clinical response to this agent is associated with leukemic-cell differentiation and is linked to the expression of an aberrant RAR-alpha nuclear receptor.
Journal Article
Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
Valerie W. Rusch,José Baselga,Carlos Cordon-Cardo,J. Orazem,Muhammad B. Zaman,Syed A. Hoda,J. Mcintosh,Jonathan M. Kurie,Ethan Dmitrovsky +8 more
TL;DR: Differential expression of EGFR and its ligands in tumor specimens compared to uninvolved lung is a common event in NSCLC and may participate in tumor growth without necessarily influencing tumor progression or histology, indicating that histologically dissimilar tumors can express similar components of autocrine or paracrine growth factor loops.
Journal ArticleDOI
Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia.
Josephia R. F. Muindi,Stanley R. Frankel,Wilson H. Miller,Ann A. Jakubowski,David A. Scheinberg,Charles W. Young,Ethan Dmitrovsky,Raymond P. Warrell +7 more
TL;DR: Results indicate that clinical relapse and "resistance" to continuous treatment with all-trans RA in APL is associated with progressive reduction of plasma concentrations, potentially to levels below those that sustain differentiation of leukemic cells in vivo.