E
Edward E. Lemmens
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 26
Citations - 5814
Edward E. Lemmens is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Priming (immunology) & Antigen. The author has an hindex of 18, co-authored 24 publications receiving 5260 citations.
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Journal ArticleDOI
CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes
Edith M. Janssen,Edward E. Lemmens,Tom Wolfe,Urs Christen,Matthias von Herrath,Stephen P. Schoenberger +5 more
TL;DR: The results demonstrate that T-cell help is ‘programmed’ into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen.
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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Leticia Corrales,Laura Hix Glickman,Sarah M. McWhirter,David B. Kanne,Kelsey E. Sivick,George E. Katibah,Seng-Ryong Woo,Edward E. Lemmens,Tamara Banda,Justin Leong,Ken Metchette,Thomas W. Dubensky,Thomas F. Gajewski +12 more
TL;DR: It injection of STING agonists induced profound regression of established tumors in mice and generated substantial systemic immune responses capable of rejecting distant metastases and providing long-lived immunologic memory.
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Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
TL;DR: It is found that naïve CTLs become committed after as little as 2 h of exposure to APCs and that their subsequent division and differentiation can occur without the need for further antigenic stimulation of the daughter cells, whether priming is in vitro or in vivo.
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CD4 + T-cell help controls CD8 + T-cell memory via TRAIL-mediated activation-induced cell death
Edith M. Janssen,Nathalie Droin,Edward E. Lemmens,Michael J. Pinkoski,Steven J. Bensinger,Benjamin D. Ehst,Thomas S. Griffith,Douglas R. Green,Stephen P. Schoenberger +8 more
TL;DR: Regulation of Trail expression can account for the role of CD4+ T cells in the generation of CD8+ T cell memory and represents a novel mechanism for controlling adaptive immune responses.
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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Juan Fu,David B. Kanne,Meredith L. Leong,Laura Hix Glickman,Sarah M. McWhirter,Edward E. Lemmens,Ken Mechette,Justin Leong,Peter Lauer,Weiqun Liu,Kelsey E. Sivick,Qi Zeng,Kevin C. Soares,Lei Zheng,Daniel A. Portnoy,Joshua J. Woodward,Drew M. Pardoll,Thomas W. Dubensky,Young J. Kim +18 more
TL;DR: The authors modified the cyclic dinucleotides to strengthen their binding to human STING, increasing their antitumor activity and showed that treatment with STINGVAX caused cancer cells to up-regulate PD-L1, a protein that suppresses the immune response.