T
Tom Wolfe
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 34
Citations - 3667
Tom Wolfe is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Cytotoxic T cell & CTL*. The author has an hindex of 24, co-authored 34 publications receiving 3536 citations. Previous affiliations of Tom Wolfe include Novo Nordisk & Scripps Research Institute.
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Journal ArticleDOI
CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes
Edith M. Janssen,Edward E. Lemmens,Tom Wolfe,Urs Christen,Matthias von Herrath,Stephen P. Schoenberger +5 more
TL;DR: The results demonstrate that T-cell help is ‘programmed’ into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen.
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Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance.
Maya F. Kotturi,Iain Scott,Tom Wolfe,Bjoern Peters,John Sidney,Hilde Cheroutre,Matthias von Herrath,Michael J. Buchmeier,Howard M. Grey,Alessandro Sette +9 more
TL;DR: Results indicate that an intrinsicproperty of the epitope (MHC binding affinity) and an intrinsic property of the host (naive precursor frequency) jointly dictate the immunodominance hierarchy of CD8+ T cell responses.
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Autoreactive CD4+ T Cells Protect from Autoimmune Diabetes via Bystander Suppression Using the IL-4/Stat6 Pathway
Dirk Homann,Andreas Holz,Adrian Bot,Bryan Coon,Tom Wolfe,Jacob S. Petersen,Thomas Dyrberg,Michael J. Grusby,Matthias von Herrath +8 more
TL;DR: The generation and characterization of insulin B chain-specific "autoreactive" CD4+ regulatory T cells that locally suppress diabetogenic T cell responses against an unrelated self-antigen in a virus-induced model for type 1 diabetes are reported.
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Impaired Immunoproteasome Assembly and Immune Responses in PA28−/− Mice
Tobias Preckel,Wai-Ping Fung-Leung,Zeling Cai,A Vitiello,Luisa Salter-Cid,Ola Winqvist,Tom Wolfe,Matthias von Herrath,Ana Angulo,Peter Ghazal,Jiing Dwan Lee,Anne M. Fourie,Ying Wu,Jesse Chung Sean Pang,Karen Ngo,Per A. Peterson,Klaus Früh,Young Yang +17 more
TL;DR: It is shown that PA28 is necessary for immunoproteasome assembly and is required for efficient antigen processing, thus demonstrating the importance of PA28-mediated proteasome function in immune responses.
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CD40L Blockade Prevents Autoimmune Diabetes by Induction of Bitypic NK/DC Regulatory Cells
Dirk Homann,Angelika Jahreis,Tom Wolfe,Tom Wolfe,Anna Hughes,Bryan Coon,Marianne J. B. van Stipdonk,Kiley R. Prilliman,Stephen P. Schoenberger,Matthias von Herrath,Matthias von Herrath +10 more
TL;DR: It is demonstrated that a single episode of CD40L blockade during development of the autoaggressive immune response completely prevented autoimmune disease in the RIP-LCMV mouse model for virally induced type 1 diabetes.