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Daniel A. Portnoy
Researcher at University of California, Berkeley
Publications - 190
Citations - 26527
Daniel A. Portnoy is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Listeria monocytogenes & Listeriolysin O. The author has an hindex of 84, co-authored 186 publications receiving 24841 citations. Previous affiliations of Daniel A. Portnoy include Rockefeller University & Oregon Health & Science University.
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Journal ArticleDOI
Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
TL;DR: Once inside a host cell, the infecting Listeria and their progeny can spread from cell to cell by remaining intracellular and thus bypass the humoral immune system of the organism.
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Role of hemolysin for the intracellular growth of Listeria monocytogenes.
TL;DR: Hemolytic-positive revertants were selected after passage of the hly- mutants through monolayers of J774 cells, and in each case, the hemolytic revertants possessed the 58-kD polypeptide, were capable of intracellular growth in tissue culture monolayer and were virulent for mice.
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c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
TL;DR: Cyclic diadenosine monophosphate (c-di-AMP) represents a putative bacterial secondary signaling molecule that triggers a cytosolic pathway of innate immunity and is predicted to be present in a wide variety of bacteria and archea.
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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Koichi Tabeta,Kasper Hoebe,Edith M. Janssen,Xin Du,Philippe Georgel,Karine Crozat,Suzanne Mudd,Navjiwan Mann,Sosathya Sovath,Jason Goode,Louis Shamel,Anat A. Herskovits,Daniel A. Portnoy,Michael P. Cooke,Lisa M. Tarantino,Tim Wiltshire,Benjamin E. Steinberg,Sergio Grinstein,Bruce Beutler +18 more
TL;DR: 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9, suggests communication between these organellar systems.
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Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis.
TL;DR: Yersinia enterocolitica isolates harboring a particular species of plasmid deoxyribonucleic acid showed a high degree of lethality for gerbils and caused the detachment of HEp-2 tissue cell monolayers, but invasiveness of HEP-2 cells was shown not to be a plasmids-mediated property.