Edward G. Rowan

TL;DR: Toxins that have unrelated structures but similar functions possess conserved key functional residues, organized in an identical topology, suggesting a convergent functional evolution for these small proteins.

TL;DR: In this paper, the late stages of this electrophysiological effect temporally coincide with the loss of heavy neurofilament and type III β-tubulin immunostaining and structural breakdown of the nerve terminal, as demonstrated by electron microscopy.

TL;DR: It is shown that the late stages of this electrophysiological effect temporally coincide with the loss of heavy neurofilament and type III beta-tubulin immunostaining and structural breakdown of the nerve terminal, as demonstrated by electron microscopy.

TL;DR: The studies provide a detailed mechanism by which loss of axonal conduction can occur in a distal dominant pattern as observed in a proportion of patients with motor axonal Guillain-Barré syndrome, and also provide an explanation for the occurrence of rapid recovery from complete paralysis and electrophysiological in-excitability.

TL;DR: The in vitro sciatic nerve model appears of limited use for analysing electrophysiologically the effects of anti-ganglioside antibodies on nerve function, possibly because its short-term viability and isolation from circulating systemic factors do not permit the evolution of an inflammatory lesion of sufficient magnitude to induce overt electrophYSiological abnormalities.