J
Jaap J. Plomp
Researcher at Leiden University Medical Center
Publications - 100
Citations - 7851
Jaap J. Plomp is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Neuromuscular junction & Myasthenia gravis. The author has an hindex of 41, co-authored 96 publications receiving 7124 citations. Previous affiliations of Jaap J. Plomp include Leiden University & University of Glasgow.
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Journal ArticleDOI
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
Matthijs Verhage,Ascanio S. Maia,Jaap J. Plomp,Arjen B. Brussaard,J H Heeroma,H. Vermeer,Ruud F. Toonen,Robert E. Hammer,T K van den Berg,Markus Missler,Hans J. Geuze,Thomas C. Südhof +11 more
TL;DR: Synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does, and neurotransmitter secretion probably functions to validate already established synaptic connections.
Journal ArticleDOI
A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression
Arn M. J. M. van den Maagdenberg,Daniela Pietrobon,Tommaso Pizzorusso,Simon Kaja,Ludo A. M. Broos,Tiziana Cesetti,Rob C. G. van de Ven,Angelita Tottene,Jos van der Kaa,Jaap J. Plomp,Rune R. Frants,Michel D. Ferrari +11 more
TL;DR: The data show that the increased susceptibility for CSD and aura in migraine may be due to cortical hyperexcitability, and the R192Q FHM-1 mouse is a promising animal model to study migraine mechanisms and treatments.
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Acquired neuromyotonia: evidence for autoantibodies directed against K+ channels of peripheral nerves.
Paul Shillito,Peter C. M. Molenaar,Angela Vincent,Angela Vincent,Katherine Leys,Wang Zheng,Rutgeris J. van den Berg,Jaap J. Plomp,Gertrudis Th. H. Van Kempen,Guy Chauplannaz,Axel R. Wintzen,J. Gert van Dijk,John Newsom-Davis +12 more
TL;DR: It is concluded that at least some patients with acquired neuromyotonia have antibodies directed against aminopyridine‐ or α‐dendrotoxin‐sensitive K+ channels in motor and sensory neurons, and they are likely to be implicated in the disease process.
Journal ArticleDOI
Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
G Jansen,Patricia J. T. A. Groenen,Dietmar Bächner,Paul H.K. Jap,Marga Coerwinkel,Frank Oerlemans,W. van den Broek,B. Gohlsch,Dirk Pette,Jaap J. Plomp,Peter C. M. Molenaar,M. G. J. Nederhoff,C.J.A. van Echteld,Marieke C. J. Dekker,Anton Berns,Horst Hameister,Bé Wieringa +16 more
TL;DR: The contention that simple loss– or gain–of–expression of DMPK is not the only crucial requirement for development of the disease is strengthened.
Journal ArticleDOI
Monoclonal antibodies raised against Guillain-Barré syndrome–associated Campylobacter jejuni lipopolysaccharides react with neuronal gangliosides and paralyze muscle-nerve preparations
Carl S. Goodyear,Graham M. O'Hanlon,Jaap J. Plomp,Eric R. Wagner,Ian Morrison,J. Veitch,Lynne Cochrane,Roland W. M. Bullens,Peter C. M. Molenaar,Joe Conner,Hugh J. Willison +10 more
TL;DR: Support is provided for the molecular mimicry hypothesis as a mechanism for the induction of cross-reactive pathogenic anti-ganglioside/LPS antibodies in postinfectious neuropathies.