E
Edward S. Mocarski
Researcher at Emory University
Publications - 313
Citations - 26352
Edward S. Mocarski is an academic researcher from Emory University. The author has contributed to research in topics: Viral replication & Human cytomegalovirus. The author has an hindex of 88, co-authored 305 publications receiving 24356 citations. Previous affiliations of Edward S. Mocarski include University of Bologna & Tokai University.
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Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
TL;DR: Mouse cytomegalovirus encodes an MHC-like protein that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice, and this viral protein engages a related activating receptor and confers host protection.
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RIP3 mediates the embryonic lethality of caspase-8-deficient mice
William J. Kaiser,Jason W. Upton,Alyssa B. Long,Devon Livingston-Rosanoff,Lisa P. Daley-Bauer,Razqallah Hakem,Tamara Caspary,Edward S. Mocarski +7 more
TL;DR: It is found that RIP3 is responsible for the mid-gestational death of Casp8-deficient embryos and together completely dispensable for mammalian development.
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Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
William J. Kaiser,Haripriya Sridharan,Chunzi Huang,Pratyusha Mandal,Jason W. Upton,Peter J. Gough,Clark A. Sehon,Robert W. Marquis,John Bertin,Edward S. Mocarski +9 more
TL;DR: Two small molecule RIP3 kinase inhibitors are described and employ them to demonstrate the common requirement for RIP3 Kinase in programmed necrosis induced by RIP1-RIP3, DAI- RIP3, and TRIF-RIP 3 complexes.
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Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains.
TL;DR: A dramatic level of genome sequence complexity is revealed that may explain the differences that these strains exhibit in virulence and tissue tropism and suggests that wild-type virus carries more than 220 genes, some of which are lost by large-scale deletion and rearrangement of the UL/b' region during laboratory passage.
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DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA
TL;DR: A role for DAI is unveiled as the RIP3 partner mediating virus-induced necrosis analogous to the RIP1-RIP3 complex controlling death receptor-induced necroptosis.