Journal ArticleDOI
Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
TLDR
Mouse cytomegalovirus encodes an MHC-like protein that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice, and this viral protein engages a related activating receptor and confers host protection.Abstract:
Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogenread more
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Functions of natural killer cells
Eric Vivier,Elena Tomasello,Elena Tomasello,Myriam Baratin,Myriam Baratin,Thierry Walzer,Thierry Walzer,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: Although NK cells might appear to be redundant in several conditions of immune challenge in humans, NK cell manipulation seems to hold promise in efforts to improve hematopoietic and solid organ transplantation, promote antitumor immunotherapy and control inflammatory and autoimmune disorders.
Journal ArticleDOI
Nk cell recognition
TL;DR: The structure, function, and ligand specificity of the receptors responsible for NK cell recognition are reviewed and the role of EMT inNK cell recognition is reviewed.
Journal ArticleDOI
Innate or Adaptive Immunity? The Example of Natural Killer Cells
Eric Vivier,David H. Raulet,Alessandro Moretta,Michael A. Caligiuri,Laurence Zitvogel,Lewis L. Lanier,Wayne M. Yokoyama,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development.
Journal ArticleDOI
Siglecs and their roles in the immune system
TL;DR: The postulated functions of the recently discovered CD33-related Siglecs are discussed and the factors that seem to be driving their rapid evolution are considered.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
References
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TL;DR: Three-dimensional position-specific scoring matrix, 3D-PSSM, combines the power of multiple sequence profiles with knowledge of protein structure to provide enhanced recognition and thus functional assignment of newly sequenced genomes.
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Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.
Veronika Groh,Rebecca Rhinehart,Julie Randolph-Habecker,Max S. Topp,Stanley R. Riddell,Thomas Spies +5 more
TL;DR: Infection by cytomegalovirus resulted in substantial increases in MIC on cultured fibroblast and endothelial cells and was associated with induced MIC expression in interstitial pneumonia, and NKG2D functioned as a costimulatory receptor that can substitute for CD28.
Journal ArticleDOI
Natural killer cells, viruses and cancer.
TL;DR: The emerging evidence that natural killer cells have an important role in vivo in immune defence is reviewed.
Journal ArticleDOI
MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells
TL;DR: The results indicate that NK cells may possess inhibitory receptors that specifically recognize MHC class I antigens, and as-much as Ly-49+ effector cells cannot be stimulated to lyse H–2Dd targets, the results indicate this allospecificity should provide insight into the molecular mechanisms of NK cell recognition.
Journal ArticleDOI
Vital involvement of a natural killer cell activation receptor in resistance to viral infection.
Michael G. Brown,Ayotunde O. Dokun,Ayotunde O. Dokun,Jonathan W. Heusel,Hamish R. C. Smith,Diana L. Beckman,Erika A. Blattenberger,Chad Dubbelde,Laurie R. Stone,Anthony A. Scalzo,Wayne M. Yokoyama +10 more
TL;DR: It is determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo.