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Ann E. Campbell
Researcher at Eastern Virginia Medical School
Publications - 32
Citations - 2619
Ann E. Campbell is an academic researcher from Eastern Virginia Medical School. The author has contributed to research in topics: Gene & Viral replication. The author has an hindex of 18, co-authored 32 publications receiving 2538 citations. Previous affiliations of Ann E. Campbell include American Cyanamid.
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Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
TL;DR: Mouse cytomegalovirus encodes an MHC-like protein that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice, and this viral protein engages a related activating receptor and confers host protection.
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Age-Related Impaired Type 1 T Cell Responses to Influenza: Reduced Activation Ex Vivo, Decreased Expansion in CTL Culture In Vitro, and Blunted Response to Influenza Vaccination In Vivo in the Elderly
TL;DR: There is a decline in the type 1 T cell response to influenza with age that may help explain the age-related decline in vaccine efficacy and the increases in influenza morbidity and mortality.
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A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface
Maurits F. Kleijnen,Johannes B. Huppa,Pero Lučin,Siddhartha Mukherjee,Helen E. Farrell,Ann E. Campbell,Ulrich H. Koszinowski,Ann B. Hill,Hidde L. Ploegh,Hidde L. Ploegh +9 more
TL;DR: An MCMV‐encoded glycoprotein, gp34, is identified and characterized, which tightly associates with properly conformed MHC class I molecules in the ER, which may counteract class I retention.
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Role of Murine Cytomegalovirus US22 Gene Family Members in Replication in Macrophages
Carine Ménard,Markus Wagner,Zsolt Ruzsics,Karina Holak,Wolfram Brune,Ann E. Campbell,Ulrich H. Koszinowski +6 more
TL;DR: The comprehensive set of mutants of the US22 gene family suggests that individual family members have diverged through evolution to serve a variety of functions for the virus.
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The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence
TL;DR: The murine cytomegalovirus (MCMV) model has provided insight into the immunological environment of the salivary glands and the unqiue virus–host relationship of this organ.