E
Edward S. Stenroos
Researcher at Rutgers University
Publications - 25
Citations - 9283
Edward S. Stenroos is an academic researcher from Rutgers University. The author has contributed to research in topics: Autism & Allele. The author has an hindex of 16, co-authored 25 publications receiving 8654 citations. Previous affiliations of Edward S. Stenroos include University of Medicine and Dentistry of New Jersey.
Papers
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Journal ArticleDOI
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
TL;DR: A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype.
Journal ArticleDOI
Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23
Mihael H. Polymeropoulos,J. J. Higgins,Lawrence I. Golbe,William G. Johnson,Susan E. Ide,Giuseppe Di Iorio,G. Sanges,Edward S. Stenroos,Lana T. Pho,Alejandro A. Schäffer,Alice M. Lazzarini,Robert L. Nussbaum,Roger C. Duvoisin +12 more
TL;DR: In this article, genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380.
Journal ArticleDOI
Ataxin-3 Interactions with Rad23 and Valosin-Containing Protein and Its Associations with Ubiquitin Chains and the Proteasome Are Consistent with a Role in Ubiquitin-Mediated Proteolysis
TL;DR: It is reported that ataxin-3 interacts with ubiquitinated proteins, can bind the proteasome, and, when the gene harbors an expanded repeat length, can interfere with the degradation of a well-characterized test substrate.
Journal ArticleDOI
New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy?
William G. Johnson,Edward S. Stenroos,John R. Spychala,Sansnee Chatkupt,Sue X. Ming,Steven Buyske +5 more
TL;DR: It is found that homozygosity for this deletion allele was significantly more frequent in SB mothers, but not in SB fathers or patients, compared with controls and was associated with a significantly increased odds ratio (OR) of being an SB mother compared with other genotypes.
Patent
Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
TL;DR: In this article, a method for identifying individuals who are genetically susceptible to having offspring with a developmental disorder is presented, and methods of diagnosing, preventing and treating developmental disorders such as schizophrenia are also provided.