Edward V. Nunes

TL;DR: It is more difficult to initiate patients to XR-NTX than BUP-NX, and this negatively affected overall relapse, but once initiated, both medications were equally safe and effective.

TL;DR: Antidepressant medication exerts a modest beneficial effect for patients with combined depressive- and substance-use disorders, and care should be exercised in the diagnosis of depression-either by observing depression to persist during at least a brief period of abstinence or through efforts by clinical history to screen out substance-related depressive symptoms.

TL;DR: In this paper, a meta-analysis of placebo-controlled trials was conducted to investigate whether to treat depression in the setting of ongoing substance abuse, finding that clinicians working with substance-dependent patients are often reluctant, for a variety of reasons, to initiate specific antidepressant treatment.

TL;DR: XR-NTX represents a new treatment option that is distinct from opioid agonist maintenance treatment and might improve acceptance of opioid dependence pharmacotherapy and provide a useful treatment option for many patients.

TL;DR: Results suggest that mild cognitive impairments negatively affect retention in outpatient CBT treatment for cocaine dependence, and modified behavioral and pharmacologic interventions should be considered to target mild cognitive impairment to improve substance treatment outcome.