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Eiji Sugiyama
Researcher at University of Toyama
Publications - 55
Citations - 1490
Eiji Sugiyama is an academic researcher from University of Toyama. The author has contributed to research in topics: Internal medicine & Rheumatoid arthritis. The author has an hindex of 18, co-authored 42 publications receiving 1382 citations.
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Journal ArticleDOI
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
Yasufumi Masaki,Lingli Dong,Lingli Dong,Nozomu Kurose,Kazuko Kitagawa,Yuko Morikawa,Motohisa Yamamoto,Hiroki Takahashi,Yasuhisa Shinomura,Kohzoh Imai,Takako Saeki,Atsushi Azumi,Shinji Nakada,Eiji Sugiyama,Shoko Matsui,Tomoki Origuchi,Susumu Nishiyama,Isao Nishimori,Takayuki Nojima,Kazunori Yamada,Mitsuhiro Kawano,Yoh Zen,Masahiko Kaneko,Kana Miyazaki,Kazuo Tsubota,Katsumi Eguchi,Kouichi Tomoda,Toshioki Sawaki,Takafumi Kawanami,Masao Tanaka,Toshihiro Fukushima,Susumu Sugai,Hisanori Umehara +32 more
TL;DR: There are considerable clinical and pathological differences between IgG4+MOLPS and SS, and based on the clinical features and good response to glucocorticoids, a new clinical entity is proposed: IgG 4+MolPS.
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Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms
R Hayashi,N Yamashita,Shoko Matsui,T Fujita,Jun Araya,Kazuhiko Sassa,N Arai,Y Yoshida,Tatsuhiko Kashii,M Maruyama,Eiji Sugiyama,Masashi Kobayashi +11 more
TL;DR: It is suggested that bradykinin appears to be involved in the inflammatory reaction leading to acute lung injury through stimulating interleukin-6 and interleukain-8 production by lung fibroblasts through the extracellular signal-regulated protein kinase 1/2 and p38 mitogen-activated protein Kinase pathway-dependent activation in human lung fibrasts.
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Activation of peroxisome proliferator-activated receptor γ inhibits TNF-α-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression
Hiroyuki Hounoki,Eiji Sugiyama,Saad Gad-Kamel Mohamed,Kouichiro Shinoda,Hirofumi Taki,Hekmat Osman Abdel-Aziz,Muneharu Maruyama,Masashi Kobayashi,Tatsuro Miyahara +8 more
TL;DR: It is demonstrated that 15d-PGJ2 and ciglitazone down-regulate TNF-alpha-mediated osteoclast differentiation in human cells, in part via suppression of the action of MCP-1.
Journal ArticleDOI
Ionizing radiation enhances matrix metalloproteinase-2 production in human lung epithelial cells.
Jun Araya,Muneharu Maruyama,Kazuhiko Sassa,Tadashi Fujita,Ryuji Hayashi,Shoko Matsui,Tatsuhiko Kashii,Naohiro Yamashita,Eiji Sugiyama,Masashi Kobayashi +9 more
TL;DR: Results indicate that MMP-2 expression by human lung epithelial cells is involved in radiation-induced lung injury, and ionizing radiation increased the level of M MP-2 mRNA.
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Interleukin‐1α and tumor necrosis factor α synergistically stimulate prostaglandin E2‐dependent production of interleukin‐11 in rheumatoid synovial fibroblasts
Takemine Mino,Eiji Sugiyama,Hirofumi Taki,Arihiko Kuroda,Naohiro Yamashita,Muneharu Maruyama,Masashi Kobayashi +6 more
TL;DR: It is suggested that IL-1alpha and TNFalpha synergistically stimulate the production of IL-11 via their effects on PGE2 production in the rheumatoid joint, and that atypical PKC may be another target for down-regulation of IL -11, the bone resorption-associated cytokine.