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Yasuhisa Shinomura
Researcher at Sapporo Medical University
Publications - 395
Citations - 23547
Yasuhisa Shinomura is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 71, co-authored 395 publications receiving 22064 citations. Previous affiliations of Yasuhisa Shinomura include Osaka University & St. Marianna University School of Medicine.
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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Seiichi Hirota,Koji Isozaki,Yasuhiro Moriyama,Koji Hashimoto,Toshirou Nishida,Shingo Ishiguro,Kiyoshi Kawano,Masato Hanada,Akihiko Kurata,Masashi Takeda,Ghulam Muhammad Tunio,Yuji Matsuzawa,Yuzuru Kanakura,Yasuhisa Shinomura,Yukihiko Kitamura +14 more
TL;DR: Sequencing of c-kit complementary DNA from five GISTs revealed mutations in the region between the transmembrane and tyrosine kinase domains, suggesting that the mutations contribute to tumor development.
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Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors
Seiichi Hirota,Akiko Ohashi,Toshirou Nishida,Koji Isozaki,Kazuo Kinoshita,Yasuhisa Shinomura,Yukihiko Kitamura +6 more
TL;DR: The gain-of-function mutations of PDGFR alpha appear to play an important role in development of GISTs without KIT mutations.
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Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
Minoru Toyota,Hiromu Suzuki,Yasushi Sasaki,Reo Maruyama,Kohzoh Imai,Yasuhisa Shinomura,Takashi Tokino +6 more
TL;DR: The results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR/c CpG island, which bidirectionally regulates miR’s 34b-34c and 4B-cell translocation gene 4, is a frequent target of epigenetic silencing in CRC.
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Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
Yasufumi Masaki,Lingli Dong,Lingli Dong,Nozomu Kurose,Kazuko Kitagawa,Yuko Morikawa,Motohisa Yamamoto,Hiroki Takahashi,Yasuhisa Shinomura,Kohzoh Imai,Takako Saeki,Atsushi Azumi,Shinji Nakada,Eiji Sugiyama,Shoko Matsui,Tomoki Origuchi,Susumu Nishiyama,Isao Nishimori,Takayuki Nojima,Kazunori Yamada,Mitsuhiro Kawano,Yoh Zen,Masahiko Kaneko,Kana Miyazaki,Kazuo Tsubota,Katsumi Eguchi,Kouichi Tomoda,Toshioki Sawaki,Takafumi Kawanami,Masao Tanaka,Toshihiro Fukushima,Susumu Sugai,Hisanori Umehara +32 more
TL;DR: There are considerable clinical and pathological differences between IgG4+MOLPS and SS, and based on the clinical features and good response to glucocorticoids, a new clinical entity is proposed: IgG 4+MolPS.
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Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
Yoshihiro Kamada,Shinji Tamura,Shinichi Kiso,Hitoshi Matsumoto,Yukiko Saji,Yuichi Yoshida,Koji Fukui,Norikazu Maeda,Hitoshi Nishizawa,Hiroyuki Nagaretani,Yoshihisa Okamoto,Shinji Kihara,Jun-ichiro Miyagawa,Yasuhisa Shinomura,Tohru Funahashi,Yuji Matsuzawa +15 more
TL;DR: The findings indicate that adiponectin attenuates liver fibrosis and could be a novel approach in its prevention.