Eirini Lionaki

TL;DR: In this Review, Tavernarakis and colleagues describe recent advances in delineating the molecular mechanisms that mediate mitophagy, and discuss the complex roles of this pathway in physiological and pathological contexts.

TL;DR: This work shows that mitophagy, a selective type of autophagy targeting mitochondria for degradation, interfaces with mitochondrial biogenesis to regulate mitochondrial content and longevity in Caenorhabditis elegans and reveals a homeostatic feedback loop that integrates metabolic signals to coordinate the biogenesis and turnover of mitochondria.

TL;DR: It is found that age-related mitophagy decline causes progressive accumulation of mitochondria in the nematode Caenorhabditis elegans, and coordination between mitochondrial biogenesis andMitophagy is essential for proper mitochondrial homeostasis.

TL;DR: The signaling cascades and molecular mechanisms that govern the process of mitophagy are reviewed and their involvement in ageing and neurodegeneration is discussed.

TL;DR: Recent findings in invertebrates that contribute to advance understanding of the molecular links between autophagy and the regulation of ageing are surveyed and related mechanisms in other organisms are considered and their similarities and idiosyncratic features are discussed in a comparative manner.