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Ekaterina Bobrovnikova-Marjon
Researcher at University of Pennsylvania
Publications - 14
Citations - 2432
Ekaterina Bobrovnikova-Marjon is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 12, co-authored 14 publications receiving 2094 citations. Previous affiliations of Ekaterina Bobrovnikova-Marjon include Agios Pharmaceuticals.
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Journal ArticleDOI
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
Jiangbin Ye,Monika Kumanova,Lori S. Hart,Kelly L. Sloane,Haiyan Zhang,Diego Nicolás de Panis,Ekaterina Bobrovnikova-Marjon,J. Alan Diehl,David Ron,Constantinos Koumenis +9 more
TL;DR: It is concluded that the GCN2‐eIF2α‐ATF4 pathway is critical for maintaining metabolic homeostasis in tumour cells, making it a novel and attractive target for anti‐tumour approaches.
Journal ArticleDOI
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
Ekaterina Bobrovnikova-Marjon,Christina Grigoriadou,Dariusz Pytel,Fangliang Zhang,Jiangbin Ye,Constantinos Koumenis,Douglas R. Cavener,J A Diehl +7 more
TL;DR: The data reveal that PERK-dependent signaling is used during both tumor initiation and expansion to maintain redox homeostasis, thereby facilitating tumor growth.
Journal ArticleDOI
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.
Alvaro Avivar-Valderas,Eduardo Salas,Ekaterina Bobrovnikova-Marjon,J. Alan Diehl,Chandandeep Nagi,Jayanta Debnath,Julio A. Aguirre-Ghiso +6 more
TL;DR: It is shown that the endoplasmic reticulum kinase PERK facilitates survival of ECM-detached cells by concomitantly promoting autophagy, ATP production, and an antioxidant response, and it is proposed that the normal proautophagic and antioxidant PERK functions may be hijacked to promote the survival ofECM- Detached tumor cells in DCIS lesions.
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HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma
Bo Qiu,Daniel Ackerman,Danielle J. Sanchez,Bo Li,Joshua D. Ochocki,Alison Grazioli,Ekaterina Bobrovnikova-Marjon,J. Alan Diehl,Brian Keith,M. Celeste Simon,M. Celeste Simon +10 more
TL;DR: It is demonstrated that Hif2α promotes lipid storage, ER homeostasis, and cell viability in ccRCC via upregulation of the LD coat protein PLIN2, revealing a novel function for the well-documented "clear-cell" phenotype and identifying ER stress as a targetable vulnerability created by HIF2α/PLIN2 suppression in this common renal malignancy.
Journal ArticleDOI
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
Ekaterina Bobrovnikova-Marjon,Georgia Hatzivassiliou,Christina Grigoriadou,Margarita Romero,Douglas R. Cavener,Craig B. Thompson,J. Alan Diehl +6 more
TL;DR: Loss of PERK inhibits expression of FAS, ACL, and SCD1 in immortalized murine embryonic fibroblasts when cultured under conditions favoring adipocyte differentiation, implicate PERK as a physiologically relevant regulator of the lipogenic pathway.