M
Monika Kumanova
Researcher at University of Pennsylvania
Publications - 3
Citations - 700
Monika Kumanova is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Microdissection & Endothelial stem cell. The author has an hindex of 3, co-authored 3 publications receiving 612 citations.
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Journal ArticleDOI
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
Jiangbin Ye,Monika Kumanova,Lori S. Hart,Kelly L. Sloane,Haiyan Zhang,Diego Nicolás de Panis,Ekaterina Bobrovnikova-Marjon,J. Alan Diehl,David Ron,Constantinos Koumenis +9 more
TL;DR: It is concluded that the GCN2‐eIF2α‐ATF4 pathway is critical for maintaining metabolic homeostasis in tumour cells, making it a novel and attractive target for anti‐tumour approaches.
Journal ArticleDOI
Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo
TL;DR: An essential role for Foxd3 is demonstrated in two nonoverlapping progenitor cell populations that require different secreted factors to maintain their multipotent properties in vitro and give rise to divergent tissues in vivo, providing support for the hypothesis that there are conserved molecular mechanisms for maintaining the self-renewing properties of diverse progenitors cell types.
Journal ArticleDOI
In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.
Diane Marotta,Jayashree Karar,W. Timothy Jenkins,Monika Kumanova,Kevin Jenkins,John W. Tobias,Donald Baldwin,Artemis G. Hatzigeorgiou,Panagiotis Alexiou,Sydney M. Evans,Rodolfo M. Alarcon,Amit Maity,Cameron J. Koch,Constantinos Koumenis +13 more
TL;DR: This is the first study to analyze the influence of hypoxia on mRNA levels in vivo and can be readily adapted to obtain a comprehensive picture of hypoxic regulation of gene expression and its influence on biological functions in solid tumors.