E
Ekaterina M. Merzlyak
Researcher at Russian Academy of Sciences
Publications - 21
Citations - 3292
Ekaterina M. Merzlyak is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: T-cell receptor & Green fluorescent protein. The author has an hindex of 12, co-authored 18 publications receiving 2858 citations. Previous affiliations of Ekaterina M. Merzlyak include Russian National Research Medical University.
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Journal ArticleDOI
Bright far-red fluorescent protein for whole-body imaging.
Dmitry Shcherbo,Ekaterina M. Merzlyak,Tatiana V. Chepurnykh,Arkady F. Fradkov,Galina V. Ermakova,Elena A. Solovieva,Konstantin A. Lukyanov,Ekaterina A. Bogdanova,Andrey G. Zaraisky,Sergey Lukyanov,Dmitriy M. Chudakov +10 more
TL;DR: A far-red fluorescent protein, named Katushka, is reported, which is seven- to tenfold brighter compared to the spectrally close HcRed or mPlum, and is characterized by fast maturation as well as a high pH-stability and photostability, which makes it the protein of choice for visualization in living tissues.
Journal ArticleDOI
Bright monomeric red fluorescent protein with an extended fluorescence lifetime
Ekaterina M. Merzlyak,Joachim Goedhart,Dmitry Shcherbo,Mariya E Bulina,Aleksandr S. Shcheglov,Arkady F. Fradkov,Anna Gaintzeva,Konstantin A. Lukyanov,Sergey Lukyanov,Theodorus W. J. Gadella,Dmitriy M. Chudakov +10 more
TL;DR: TagRFP is reported, a monomeric red fluorescent protein, which is characterized by high brightness, complete chromophore maturation, prolonged fluorescence lifetime and high pH-stability, which makes it an excellent tag for protein localization studies and fluorescence resonance energy transfer (FRET) applications.
Journal ArticleDOI
A genetically encoded photosensitizer.
Maria E Bulina,Dmitriy M. Chudakov,Olga V. Britanova,Yurii G. Yanushevich,Dmitry B. Staroverov,T. V. Chepurnykh,Ekaterina M. Merzlyak,Maria Shkrob,Sergey Lukyanov,Konstantin A. Lukyanov +9 more
TL;DR: The utility of KillerRed is demonstrated for light-induced killing of Escherichia coli and eukaryotic cells and for inactivating fusions to β-galactosidase and phospholipase Cδ1 pleckstrin homology domain.
Journal ArticleDOI
Towards error-free profiling of immune repertoires
Mikhail Shugay,Olga V. Britanova,Ekaterina M. Merzlyak,Maria A. Turchaninova,Ilgar Z. Mamedov,Timur R Tuganbaev,Dmitriy A. Bolotin,Dmitry B. Staroverov,Ekaterina V. Putintseva,Karla Plevová,Carsten Linnemann,Dmitriy A. Shagin,Šárka Pospíšilová,Sergey Lukyanov,Sergey Lukyanov,Ton N. Schumacher,Dmitriy M. Chudakov +16 more
TL;DR: MIGEC (molecular identifier groups–based error correction), a strategy for high-throughput sequencing data analysis, allows for nearly absolute error correction while fully preserving the natural diversity of complex immune repertoires.
Journal ArticleDOI
Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling
Olga V. Britanova,Ekaterina V. Putintseva,Mikhail Shugay,Mikhail Shugay,Ekaterina M. Merzlyak,Maria A. Turchaninova,Dmitriy B. Staroverov,Dmitriy A. Bolotin,Sergey Lukyanov,Sergey Lukyanov,Ekaterina A. Bogdanova,Ilgar Z. Mamedov,Y B Lebedev,Dmitriy M. Chudakov,Dmitriy M. Chudakov +14 more
TL;DR: It is demonstrated that TCR β diversity per 106 T cells decreases roughly linearly with age, with significant reduction already apparent by age 40, and the percentage of naive T cells showed a strong correlation with measured TCR diversity and decreased linearly up to age 70.