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Elaine L. Leonard Puppa
Researcher at University of Maryland, Baltimore
Publications - 10
Citations - 934
Elaine L. Leonard Puppa is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Gliadin & Gluten. The author has an hindex of 6, co-authored 9 publications receiving 837 citations.
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Journal ArticleDOI
Natural history of celiac disease autoimmunity in a USA cohort followed since 1974
Carlo Catassi,Debby Kryszak,Bushra N. Bhatti,Craig Sturgeon,Kathy J. Helzlsouer,Sandra Clipp,Daniel Gelfond,Elaine L. Leonard Puppa,Anthony Sferruzza,Alessio Fasano +9 more
TL;DR: The CLUE study demonstrated that this increase in CD prevalence increased 2-fold in the CLUE cohort and 5-fold overall in the US since 1974 was due to an increasing number of subjects that lost the immunological tolerance to gluten in their adulthood.
Journal ArticleDOI
Proof of Concept of Microbiome-Metabolome Analysis and Delayed Gluten Exposure on Celiac Disease Autoimmunity in Genetically At-Risk Infants
Maria Sellitto,Guoyun Bai,Gloria Serena,W. Florian Fricke,Craig Sturgeon,Pawel Gajer,James R. White,Sara S. K. Koenig,Joyce M. Sakamoto,Dustin Boothe,Rachel E. Gicquelais,Deborah Kryszak,Elaine L. Leonard Puppa,Carlo Catassi,Carlo Catassi,Jacques Ravel,Alessio Fasano +16 more
TL;DR: It is shown that infants genetically susceptible to CD who are exposed to gluten early mount an immune response against gluten and develop CD autoimmunity more frequently than at-risk infants in which gluten exposure is delayed until 12 months of age.
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Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity.
Justin R. Hollon,Elaine L. Leonard Puppa,Bruce D. Greenwald,Eric Goldberg,Anthony L. Guerrerio,Alessio Fasano +5 more
TL;DR: Following gliadin exposure, both patients with gluten sensitivity and those with active celiac disease demonstrate a greater increase in intestinal permeability than celiacs in disease remission.
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Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients
Justin R. Hollon,Pamela Cureton,Pamela Cureton,Margaret L Martin,Elaine L. Leonard Puppa,Alessio Fasano +5 more
TL;DR: The GCED may be an effective therapeutic option for GFD-adherent NRCD patients and identifies a subgroup of patients, previously classified as RCD1, that is not truly refractory to dietary treatment.
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Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease
Karen M. Lammers,Sunaina Khandelwal,Fatima Chaudhry,Debby Kryszak,Elaine L. Leonard Puppa,Vincenzo Casolaro,Vincenzo Casolaro,Alessio Fasano +7 more
TL;DR: Induction of IL‐8 was reproduced by one of a comprehensive panel of synthetic α‐gliadin peptides and was abrogated when CXCR3 was blocked before stimulation with either gliadin or this peptide in the CD group but not in the control group, suggesting thatgliadin‐induced IL-8 production was CX CR3‐dependent gliaddin induced IL‐ 8 production only in CD.