E
Eleanor Taylor
Researcher at University of Manchester
Publications - 10
Citations - 178
Eleanor Taylor is an academic researcher from University of Manchester. The author has contributed to research in topics: Addiction & Impulsivity. The author has an hindex of 5, co-authored 6 publications receiving 132 citations.
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Journal ArticleDOI
Fusel Alcohols Regulate Translation Initiation by Inhibiting eIF2B to Reduce Ternary Complex in a Mechanism That May Involve Altering the Integrity and Dynamics of the eIF2B Body
Eleanor Taylor,Susan G. Campbell,Christian D. Griffiths,Peter J. Reid,John W. Slaven,Richard J. Harrison,Paul F. G. Sims,Graham D. Pavitt,Daniela Delneri,Mark P. Ashe +9 more
TL;DR: This study highlights a connection between the eIF2B body and the regulation of translation initiation as a response to stress in Saccharomyces cerevisiae.
Journal ArticleDOI
The detrimental effects of emotional process dysregulation on decision-making in substance dependence
TL;DR: How emotional dysregulations impact upon decision-making controlled by goal-directed and habitual action selections systems, and, in combination with a failure of prefrontal inhibitory control, mediate maladaptive decision- making observed in substance dependent individuals such that they continue drug use in spite of negative consequences, is explored.
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Acute D3 antagonist GSK598809 selectively enhances neural response during monetary reward anticipation in drug and alcohol dependence
Anna Murphy,Liam J Nestor,Liam J Nestor,John McGonigle,Louise M. Paterson,Venkataramana Boyapati,Karen D. Ersche,Remy Flechais,Shankar Kuchibatla,Antonio Metastasio,Csaba Orban,Filippo Passetti,Laurence J. Reed,Dana G. Smith,John Suckling,Eleanor Taylor,Trevor W. Robbins,Anne Lingford-Hughes,David J. Nutt,John Francis William Deakin,Rebecca Elliott +20 more
TL;DR: Functional magnetic resonance imaging findings suggest that GSK598809 may remediate reward deficits in substance dependence by modulating the neural network underlying reward anticipation but not response inhibition, suggesting that DRD3 antagonists may restore Reward deficits in addiction.
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Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task.
Liam J Nestor,Anna Murphy,John McGonigle,Csaba Orban,Laurence J. Reed,Eleanor Taylor,Remy Flechais,Louise M. Paterson,Dana G. Smith,Edward T. Bullmore,Karen D. Ersche,John Suckling,Roger Tait,Rebecca Elliott,Bill Deakin,Ilan Rabiner,Anne Lingford-Hughes,David J. Nutt,Barbara J. Sahakian,Trevor W. Robbins +19 more
TL;DR: It is confirmed that both substance‐dependent groups exhibit substantial neural deficits during an MID task, despite being in long‐term abstinence, and naltrexone treatment was unable to remediate disturbances within fronto‐striatal regions during reward anticipation and ‘missed’ rewards in either substance‐ dependent group.
Journal ArticleDOI
Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals.
Liam J Nestor,Liam J Nestor,Louise M. Paterson,Anna Murphy,John McGonigle,Csaba Orban,Laurence J. Reed,Eleanor Taylor,Remy Flechais,Dana G. Smith,Edward T. Bullmore,Karen D. Ersche,John Suckling,Rebecca Elliott,Bill Deakin,Ilan Rabiner,Anne Lingford Hughes,Barbara J. Sahakian,Trevor W. Robbins,David J. Nutt +19 more
TL;DR: It is suggested that acute naltrexone differentially amplifies neural responses within two distinct regions of a salience network during successful motor impulse control in abstinent AUD and poly‐SUD groups, which are predicted by trait impulsivity in the poly-SUD group.