E
Elena B. Lasunskaia
Researcher at State University of Norte Fluminense
Publications - 42
Citations - 1004
Elena B. Lasunskaia is an academic researcher from State University of Norte Fluminense. The author has contributed to research in topics: Mycobacterium tuberculosis & Antimycobacterial. The author has an hindex of 16, co-authored 41 publications receiving 843 citations.
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Journal ArticleDOI
Mycobacterium tuberculosis Strains of the Modern Sublineage of the Beijing Family Are More Likely To Display Increased Virulence than Strains of the Ancient Sublineage
Simone C. M. Ribeiro,Lia Lima Gomes,Eduardo P. Amaral,Marcelle R. M. de Andrade,Fabrício Moreira Almeida,Andreza Linhares Rezende,Verônica R. Lanes,Eulógio Carlos Queiroz de Carvalho,Philip Noel Suffys,Igor Mokrousov,Elena B. Lasunskaia +10 more
TL;DR: The results showed that two of the three modern Beijing strains were highly pathogenic, exhibiting levels of virulence comparable with that of the epidemic Russian strain, and suggest that genetic alterations characteristic of the modern Beijing sublineage favor selection of highly virulent bacteria.
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Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis
Eduardo P. Amaral,Simone C. M. Ribeiro,Verônica R. Lanes,Fabrício Moreira Almeida,Marcelle R. M. de Andrade,Caio César Barbosa Bomfim,Érika Machado de Salles,Karina R. Bortoluci,Robson Coutinho-Silva,Mario Hiroyuki Hirata,José M. Alvarez,Elena B. Lasunskaia,Maria Regina D'Império-Lima +12 more
TL;DR: It is proposed that the rapid intracellular growth of hypervirulent mycobacteria results in massive macrophage damage, which exacerbates pneumonia and lung necrosis by promoting widespread cell destruction and bacillus dissemination.
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Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization.
Irina V. Guzhova,Andrea Cristina Vetö Arnholdt,Zulfia A. Darieva,Alexander V. Kinev,Elena B. Lasunskaia,Kenneth Nilsson,Valery M. Bozhkov,Alexei P. Voronin,Boris A. Margulis +8 more
TL;DR: The experiments performed to investigate the influence of Hsp/Hsc70 on the reaction of U-937 cells to differentiation stimuli demonstrated that the addition of the protein prior to PMA was able to inhibit binding of proper transcription factors to double-symmetry and cAMP-response elements of the c-fos early response gene promoter.
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Emerging multidrug resistant Mycobacterium tuberculosis strains of the Beijing genotype circulating in Russia express a pattern of biological properties associated with enhanced virulence.
Elena B. Lasunskaia,Simone C. M. Ribeiro,Olga Manicheva,Lia Lima Gomes,Philip Noel Suffys,Igor Mokrousov,Lucilaine Ferrazoli,Marcelle R. M. de Andrade,Afranio Lineu Kritski,Tatiana Otten,Thereza Liberman Kipnis,Wilmar Dias da Silva,Boris Vishnevsky,Martha Maria Oliveira,Harrison Magdinier Gomes,Ida Maria Foschiani Dias Baptista,Olga Narvskaya +16 more
TL;DR: The data demonstrate that the emerging MDR strains of the Beijing genotype circulating in Russia do express a pattern of properties associated with the enhanced virulence favouring its clonal dissemination in this region.
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Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-κB-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding
Z. A. Darieva,Elena B. Lasunskaia,Mariana N. N. Campos,Thereza Liberman Kipnis,Wilmar Dias da Silva +4 more
TL;DR: The data obtained demonstrate that PI‐3K, JNK, and p38 MAPK activation by mycobacteria enhance NF‐κB‐driven gene expression contributing to the proinflammatory macrophage response, suggesting an indirect mechanism of the NF‐kkB regulation by these kinases.