K
Kenneth Nilsson
Researcher at Uppsala University
Publications - 284
Citations - 9851
Kenneth Nilsson is an academic researcher from Uppsala University. The author has contributed to research in topics: Cell culture & Cellular differentiation. The author has an hindex of 59, co-authored 277 publications receiving 9550 citations. Previous affiliations of Kenneth Nilsson include Umeå University & Uppsala University Hospital.
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Natural killer cells kill tumour cells at a given stage of differentiation.
TL;DR: The findings support the view that susceptibility to NK-cell mediated lysis may vary according to the stage of differentiation of the target cell, and that, in vivo, both normal and malignant cells are under surveillance by NK cells.
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Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines.
TL;DR: Results show that IGF-I can act as a growth factor in human MM, and they suggest that an autocrine IGF- I loop may contribute to the growth and survival in some MM cell lines.
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Formation and growth of multicellular spheroids of human origin.
J. Carlsson,Kenneth Nilsson,Bengt Westermark,Jan Pontén,Christer Sundström,Erik G. Larsson,Jonas Bergh,S. Påhlman,Christer Busch,V. P. Collins +9 more
TL;DR: The results show that many types of human cells can be cultured as spheroids and that a wide spectrum of morphological appearances and growth rates can be obtained.
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Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.
Thomas Strömberg,Anna Dimberg,Anna Hammarberg,Kristina Carlson,Anders Österborg,Kenneth Nilsson,Helena Jernberg-Wiklund +6 more
TL;DR: The combinatorial treatment with rapamycin and dexamethasone suppressed the antiapoptotic effects of exogenously added IGF-I and interleukin 6 (IL-6) as well as their stimulation of p70S6K phosphorylation.
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IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
Thomas Strömberg,Simon Ekman,Leonard Girnita,Lina Y. Dimberg,Olle Larsson,Magnus Axelson,Johan Lennartsson,Ulf Hellman,Kristina Carlson,Anders Österborg,Karin Vanderkerken,Kenneth Nilsson,Helena Jernberg-Wiklund +12 more
TL;DR: It is suggested that interfering with the IGF-1 RTK by using the cyclolignan PPP offers a novel and selective therapeutic strategy for MM.