Elena Dale

TL;DR: The pharmacological profiles of compounds that derived from these strategies and have been recently tested in clinical trials are reviewed and future directions for antidepressant research are outlined.

TL;DR: The evidence is weighed whether minocycline is indeed a bona fide microglia inhibitor and how data generated with minocyCline should be interpreted.

TL;DR: The data on how SSRIs and vortioxetine, an antidepressant with multimodal activity, affect hippocampal function, including cognitive processing, from both a preclinical and clinical perspective is reviewed.

TL;DR: This Review focuses on 5-HT receptor expression patterns within the PFC and how they influence cognitive behavior and neurotransmission, and the net effects of vortioxetine, an antidepressant acting through multiple serotonergic targets given the recent findings that vortoxetine improves cognition by modulating multiple neurotransmitter systems.

TL;DR: Results indicate that vortioxetine can increase pyramidal cell output, which leads to enhanced synaptic plasticity in the hippocampus, which may provide a cellular correlate to the observed preclinical and clinical cognition-enhancing effects of vortoxetine.