L
Li Gan
Researcher at Cornell University
Publications - 120
Citations - 10503
Li Gan is an academic researcher from Cornell University. The author has contributed to research in topics: Tauopathy & Neurodegeneration. The author has an hindex of 51, co-authored 110 publications receiving 8218 citations. Previous affiliations of Li Gan include Yale University & University of California, Berkeley.
Papers
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Journal ArticleDOI
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
Sang-Won Min,Seo-hyun Cho,Yungui Zhou,Sebastian Schroeder,Vahram Haroutunian,William W. Seeley,Eric J. Huang,Yong Shen,Eliezer Masliah,Chandrani Mukherjee,David J. Meyers,Philip A. Cole,Melanie Ott,Li Gan +13 more
TL;DR: Modulating tau acetylation could be a new therapeutic strategy to reduce tau-mediated neurodegeneration in patients at early and moderate Braak stages of tauopathy.
Journal ArticleDOI
SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling
Jennifer Y. Chen,Yungui Zhou,Sarah Mueller-Steiner,Lin Feng Chen,Hakju Kwon,Saili Yi,Lennart Mucke,Li Gan +7 more
TL;DR: It is demonstrated that NF-κB signaling in microglia is critically involved in neuronal death induced by amyloid-β (Aβ) peptides, which are widely presumed to cause Alzheimer disease, and SIRT1 is implicate in this pathway.
Journal ArticleDOI
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease
Sarah Mueller-Steiner,Yungui Zhou,Hideaki Arai,Hideaki Arai,Erik D. Roberson,Binggui Sun,Jennifer Y. Chen,Xin Wang,Gui-Qiu Yu,Luke A. Esposito,Lennart Mucke,Li Gan +11 more
TL;DR: It is demonstrated that CatB actually reduces levels of Abeta peptides, especially the aggregation-prone species Abeta1-42, through proteolytic cleavage, and likely fulfills antiamyloidogenic and neuroprotective functions.
Journal ArticleDOI
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Sang-Won Min,Xu Chen,Tara E. Tracy,Yaqiao Li,Yungui Zhou,Chao Wang,Kotaro Shirakawa,S. Sakura Minami,Erwin Defensor,Sue-Ann Mok,Peter Dongmin Sohn,Birgit Schilling,Xin Cong,Lisa M. Ellerby,Bradford W. Gibson,Jeffrey R. Johnson,Nevan J. Krogan,Mehrdad Shamloo,Jason E. Gestwicki,Eliezer Masliah,Eric Verdin,Li Gan +21 more
TL;DR: Targeting tau acetylation could be a new therapeutic strategy against human tauopathies and a critical determinant in tau homeostasis and toxicity in mice.
Journal ArticleDOI
Contribution of the Kv3.1 potassium channel to high‐frequency firing in mouse auditory neurones
TL;DR: Analysis of patch‐clamp, in situ hybridization and computer simulation techniques concludes that in mouse MNTB neurones the Kv3.1 channel contributes to the ability of these cells to lock their firing to high‐frequency inputs.