Elena Donetti

TL;DR: The in vivo activity of different 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (vastatins) on neointimal formation induced by insertion of a flexible collar around one carotid artery of normocholesterolemic rabbits was investigated.

TL;DR: Results suggest that class I HDAC inhibitors may provide a pharmacologic approach to treating type 2 diabetes, and indicate that inhibition of HDAC3 may account for the beneficial effect of the class I–selective HDAC inhibitor.

TL;DR: It is shown here that indeed WT SOD1 is modified posttranslationally in sporadic ALS and is iper-oxidized (i.e., above baseline oxidation levels) in a subset of patients with bulbar onset, providing an opportunity to develop biomarkers to subclassify ALS and devise S OD1-based therapies that go beyond the small group of Patients with mutant SOD 1.

TL;DR: It is concluded that replication-deficient adenoviruses, VSV-G pseudotyped retroviruses, and plasmid/liposome complexes can be used for gene transfer to the arterial wall using the collar method.

TL;DR: Proliferation of smooth muscle cells, assessed by direct incorporation of bromo-2'-deoxyuridine into replicating DNA, was reduced by approximately 30% and 75% in the intimal and medial tissues of rA-IM/A- IM-pretreated rabbits.