J
John Martin
Researcher at University College London
Publications - 147
Citations - 7499
John Martin is an academic researcher from University College London. The author has contributed to research in topics: Mean platelet volume & Myocardial infarction. The author has an hindex of 44, co-authored 141 publications receiving 7106 citations. Previous affiliations of John Martin include University of Wales & Queen Elizabeth Hospital Birmingham.
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The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration
TL;DR: It is shown that bleeding time depends on both platelet count and mean platelet volume, as well as platelet number, which should be considered as an index of haemostasis and its dysfunction, thrombosis.
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Human angiotensin I-converting enzyme gene and endurance performance.
TL;DR: A positive association of the I allele with elite endurance performance is supported in 91 British Olympic-standard runners and among 404 Olympic- standard athletes from 19 other mixed sporting disciplines.
Journal ArticleDOI
Cardiovascular gene therapy.
Seppo Ylä-Herttuala,John Martin +1 more
TL;DR: First experiences of VEGF gene transfer and decoy oligonucleotides in human beings have been reported, but further developments in gene-transfer vectors, gene-delivery techniques and identification of effective treatment genes will be required before the full therapeutic potential of gene therapy in cardiovascular disease can be assessed.
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Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain
TL;DR: The large, more reactive platelets might be causally related to an ongoing coronary artery obstruction in unstable angina and be associated or preceded by an increase in platelet destruction rate that is not completely compensated for by a increase in Platelet production rate.
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Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase
Caroline P.D. Wheeler-Jones,Robin Abu-Ghazaleh,Rosario Cospedal,Rebecca A. Houliston,John Martin,Ian Zachary +5 more
TL;DR: These findings provide the first evidence that V EGF can stimulate PGI2 synthesis via cPLA2‐mediated arachidonic acid release and indicate that VEGF stimulation of this biosynthetic pathway may occur, at least in part, via activation of p42/p44 MAP kinases.