There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

2 1 The innovative transport systems and the CityMobil project 10 1.1 The research questions 10 2 The state of art in the field of automatic transport systems 12 2.1 Case studies and demand studies for innovative transport systems 12 3 The design and implementation of surveys 14 3.1 Definition of experimental design 14 3.2 Questionnaire design and delivery 16 3.3 First analyses on the collected sample 18 4 Calibration of Logit Multionomial demand models 21 4.1 Methodology 21 4.2 Calibration of the “full” model. 22 4.3 Calibration of the “final” model 24 4.4 The demand analysis through the final Multinomial Logit model 25 5 The analysis of interaction between the demand and socioeconomic attributes 31 5.1 Methodology 31 5.2 Application of Mixed Logit models to the demand 31 5.3 Analysis of the interactions between demand and socioeconomic attributes through Mixed Logit models 32 5.4 Mixed Logit model and interaction between age and the demand for the CTS 38 5.5 Demand analysis with Mixed Logit model 39 6 Final analyses and conclusions 45 6.1 Comparison between the results of the analyses 45 6.2 Conclusions 48 6.3 Answers to the research questions and future developments 52

The European commission

Measuring Health: A Guide to Rating Scales and Questionnaires

Public Management Reform. A Comparative Analysis

超出生体重児に対する早期デキサメサゾン投与の有用性 : National Institute of Child Health and Human Development Neonatal research Network報告 (海外誌掲載論文の和文概要とそれに対するコメント)

Patterns of antibiotic use among adults and parents in the community: a questionnaire-based survey in a Greek urban population.

A case–control study was conducted in a rural area of Achaia in western Greece to examine the risk factors of brucellosis. The participants in the study were 414 (7.5% of the whole population of the investigated municipality). The cases (n = 140) were defined by clinical symptoms and confirmed by a positive standard agglutination test (SAT). All cases have been diagnosed between January 1997 and March 1999 either by physicians of the Local Health Center or by private practitioners. Two criteria were basic to establish the disease. The first one was clinical symptoms such as fever, fatigue, arthralgia and generalized aches and the second was a titer of SAT at least 1:160. Controls (n = 274) were matched with cases for age and gender in a 1:2 ratio. Approximately collection of controls was performed among those presented to the local Health Center for other diseases. Data were collected by the same physician via a personal interview and analyzed by logistic regression models. The overall incidence of the disease in the region was found to be 1110/100,000. Taking ‘no ownership of animals’ and ‘no contact of animals’ as the reference category, the strongest risk factor was trauma during animal delivery with an odds ratio (OR): 24.3; 95% confidence interval (CI): 8.8–67.5 following by absence of stables (OR: 14.4; 95% CI: 4.7–44.1). After application of multivariate stepwise analysis the adjusted risk factors remaining in the model were the place of residence (OR: 1.8; 95% CI: 1.1–3.1), professional occupation with animals (OR: 2.4; 95% CI: 1.2–4.8), absence of stables (OR: 9.1; 95% CI: 2.2–38.7) and trauma during animal delivery (OR: 11.2; 95% CI: 3.2–39.1). Consumption of cheese from pasteurized milk or consumption of cheese matured for over 3 months was found to be a protective factor (OR: 0.27; 95% CI: 0.11–0.67). The detection of brucellosis in animals is essential for the prevention of the disease. In addition efficient preventive measures should be established in order to eliminate the disease.

Epidemiology of human brucellosis in a rural area of north-western Peloponnese in Greece

Objective To investigate the relationships between physical, psychosocial, and individual characteristics and occurrence, chronicity, care seeking and absenteeism due to musculoskeletal complaints of the lower back and knee. Methods and participants This was a cross-sectional study among 350 nursing personnel in six hospitals in South-West Greece. Data related to physical and psychosocial workload, need for recovery, perceived general health and other risk factors for occurrence of low-back and knee complaints were collected. Odds ratios (ORs) were estimated for all relevant risk factors. Results Low-back and knee pain were reported by 51% and 23% of the subjects, respectively. A high perceived physical exertion and a moderate/bad perceived general health were the strongest risk factor for low-back and knee pain. With regard to care seeking a moderate/bad perceived general health was risk factor for both, low back and knee pain (OR=3.45 and OR=2.28; respectively). Perceived moderate/bad general health (OR=2.90) and high need for recovery (OR=2.78) were risk factors for absenteeism due to low-back pain, whereas organizational factors, high job demands (OR=4.60) and low co workers support (OR=3.13) for absenteeism due to knee pain. Age exhibited a positive relation with the disability and care seeking for both complaints although far stronger for knee. Conclusions Compared to the well-studied work related low back pain, knee complaints have been shown to cause significant burden in nursing staff. Besides general health status of individual workers, work-related psychosocial factors, like support and demand, are related with the disability and care seeking for knee complaints.

Knee and low back complaints in professional hospital nurses: occurrence, chronicity, care seeking and absenteeism.

Brucellosis continues to be an important source of morbidity in several countries, particularly among agricultural and pastoral populations. The purpose of this study was to examine if there is an effect on the incidence of human brucellosis after the implementation of an animal brucellosis control programme. The study was conducted in the Municipality of Tritaia in the Prefecture of Achaia in Western Greece during the periods 1997–1998 and 2000–2002. Health education efforts were made during 1997–1998 to make the public take preventive measures. In the time period from January 1999 to August 2002 a vaccination programme against animal brucellosis was realised in the specific region. The vaccine used was the B. melitensis Rev-1 administered by the conjuctival route. Comparisons were performed between the incidence rates of the two studied periods. There was a great fall in the incidence rate between 1997–1998 (10.3 per 1,000 population) and the period 2000–2002 after the vaccination (0.3 per 1,000 population). The considerable decrease of the human incidence rate is also observed in the period 2000–2002 among persons whose herds were not as yet vaccinated (1.4 vs. 10.3 per 1,000 population), indicating a possible role of health education in the decline of human brucellosis. The study reveals a statistically significant decline in the incidence of human brucellosis after the vaccination programme and underlines the importance of an ongoing control of animal brucellosis in the prevention of human brucellosis. The reduction of human brucellosis can be best achieved by a combination of health education and mass animal vaccination.

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Incidence of human brucellosis in a rural area in Western Greece after the implementation of a vaccination programme against animal brucellosis

Survival trends in survival for laryngeal cancer in Europe are varied. Five-year survival varied around 60-64% but numbers below 50% have been commonly reported. The aim of this study was to assess the factors influencing survival in patients with laryngeal cancer in our region. A total of 128 male and 5 female patients with larynx cancer (91 glottic and 42 supraglottic) were treated at Patras University Hospital between March 1992 and August 2004. Except 3, all were smokers and 56 (41%) heavy alcohol users. Postsurgical staging showed that most had been classified at stages III (38%) and IV (49%). By histology, 31 tumors were classified as poorly differentiated, 78 as moderately differentiated and 23 as well differentiated. All patients underwent laryngectomy with extension of the procedure where appropriate. Also, a total of 45 patients received adjuvant therapy (either chemotherapy or radiotherapy). Farmers, construction workers, professional drivers and mechanics and coffee shop and bar employees account for more than 70% of patients. Results showed that 64 (48.1%) patients died during the follow-up, 58 (43.6%) of them died from cause related to their disease. With a median follow-up of 25 months, the 5-year disease-free survival (DFS) was 53% and the 5-year overall survival (OS) was 45%. Significant prognostic factors for OS included patient age, advanced staging, heavy alcohol use and poor tumor differentiation while for DFS affected mainly by poor tumor differentiation. We conclude that the disease stage at presentation, tumor grade and alcohol consumption prove to be important predictors for the OS as well as the DFS in our series.

Eleni Jelastopulu

Papers

Patterns of antibiotic use among adults and parents in the community: a questionnaire-based survey in a Greek urban population.

Epidemiology of human brucellosis in a rural area of north-western Peloponnese in Greece

Knee and low back complaints in professional hospital nurses: occurrence, chronicity, care seeking and absenteeism.

Incidence of human brucellosis in a rural area in Western Greece after the implementation of a vaccination programme against animal brucellosis

Survival after laryngectomy: a review of 133 patients with laryngeal carcinoma.