Eleni Tzima

TL;DR: In this paper, the authors investigated the pathway upstream of integrin activation and found that PECAM-1 and VEGFR2 are sufficient to confer responsiveness to flow in heterologous cells.

TL;DR: The relationship between integrins and mechanical forces, the role ofintegrins in cellular responses to stretch and fluid flow, and propose that some of these events are mechanistically related are proposed.

TL;DR: The role of integrins and Rho are defined in a pathway leading to endothelial cell adaptation to flow by shear stress rapidly stimulates conformational activation of integrin αvβ3 in bovine aortic endothelial cells, followed by an increase in its binding to extracellular cell matrix (ECM) proteins.

TL;DR: This work shows that activation of the small GTPase Rac is essential for gene expression and for providing spatial information for shear stress‐induced cell alignment, and provides a unifying model linking three of the main responses toShear stress that mediate both normal adaptation to hemodynamic forces and inflammatory dysfunction of endothelial cells in atherosclerosis.

TL;DR: What is known about Ras and more so about Rho GTPases in mechanotransduction and the responses of cells to fluid flow is reviewed to explore possible connections and a unifying hypothesis offered.