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TL;DR: Indinavir could be crucial in addressing the outcome of cryptococcosis in immunocompromised hosts because of its direct influence on fungal virulence and blunting of the deleterious effects exerted by C. neoformans on host immune response.

TL;DR: The crude methanolic extract obtained from C. erythraea resin was chromatographed on silica gel with solvent of increasing polarity and only two compounds showed anti-PIV3 activity with a selectivity index (SI) of 66.6 and 17.5, respectively.

TL;DR: The results reported here show that IDV treatment induces an expansion of DC with CD8α phenotype in spleens of infected hosts, which could help to elucidate the immunoregulatory activity of PI and point out the beneficial effects of IDV in regulating DC functions and antifungal activity.

TL;DR: Cytomegalovirus should be included among the etiologic agents of acute appendicitis in patients with primary sclerosing cholangitis and ulcerative colitis in apparently immunocompetent subjects.

TL;DR: The present review includes peer-reviewed studies on ACC, suggesting a crucial impact on the therapeutic management of patients with bloodstream infections and sepsis, provided the presence of a hospital antimicrobial stewardship program, a 24/7 laboratory operating time and a strict collaboration between clinical microbiologist and clinician.