Showing papers by "Elio Riboli published in 1986"

Case‐control study on colorectal cancer and diet in marseilles

Abstract: A case-control study of cancer of the colon and rectum was conducted in the Marseilles region of southern France. Cases (399) and a corresponding number of controls, matched for age and sex, were included, the controls being selected from patients undergoing functional re-education for injuries or trauma which reduced their mobility. A dietary history questionnaire was used to determine the usual eating habits during the year preceding diagnosis for cases, or preceding interview for controls. The cases reported lower consumption of vegetables and oil than controls, but no differences were seen in the consumption of meat, bread, eggs or butter. The intake of several nutrients, particularly vitamins B2, B6, C, potassium, iron, magnesium and vegetable fibre, was lower among cases. However, when all these nutrients were analysed jointly and adjusted one for the other, only potassium retained a significant effect. This may be due to the high degree of colinearity between the estimated intake of many nutrients. No association was seen with fat or fibres from cereals.

Current hypotheses on the etiology of colorectal cancer. Critical review of the epidemiological evidence.

Abstract: The epidemiological evidence supporting hypotheses concerning colorectal carcinogenesis presents conflicting findings. Even the detrimental role of high fat intake and the protective effect of fibre have to be qualified. In order to improve knowledge on the etiopathogenesis of colorectal cancer, more attention should be directed to the modifiers of the action of carcinogenic or anticarcinogenic substances. Sex, age, hormonal and metabolic status should be precisely accounted for, as should the exact anatomical subsite of the cancer.