E
Elisheva Smith
Researcher at University of Southern California
Publications - 27
Citations - 1311
Elisheva Smith is an academic researcher from University of Southern California. The author has contributed to research in topics: Osteoblast & Tobamovirus. The author has an hindex of 16, co-authored 23 publications receiving 1060 citations. Previous affiliations of Elisheva Smith include University of Massachusetts Amherst.
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Journal ArticleDOI
Glucocorticoids Inhibit the Transcriptional Activity of LEF/TCF in Differentiating Osteoblasts in a Glycogen Synthase Kinase-3β-dependent and -independent Manner
Elisheva Smith,Baruch Frenkel +1 more
TL;DR: It is shown that DEX inhibition of the differentiation-related cell cycle is associated with a decrease in β-catenin levels and inhibition of LEF/TCF-mediated transcription, and cross-talk between the PI3K/Akt and Wnt signaling pathways is suggested.
Journal ArticleDOI
A New Israeli Tobamovirus Isolate Infects Tomato Plants Harboring Tm-22 Resistance Genes
Neta Luria,Elisheva Smith,Victoria Reingold,Ilana Bekelman,Moshe Lapidot,Ilan Levin,Nadav Elad,Yehudit Tam,Noa Sela,Ahmad Abu-Ras,Nadav Ezra,Ami Haberman,Liron Yitzhak,Oded Lachman,Aviv Dombrovsky +14 more
TL;DR: In samples collected from commercial cultivars across Israel, a single virus was found that caused the disease and the complete genome sequence of the new Israeli tobamovirus showed high sequence identity to the Jordanian isolate of tomato brown rugose fruit virus.
Journal ArticleDOI
Glucocorticoids Inhibit Developmental Stage-specific Osteoblast Cell Cycle DISSOCIATION OF CYCLIN A-CYCLIN-DEPENDENT KINASE 2 FROM E2F4-p130 COMPLEXES
Elisheva Smith,Rebecca A. Redman,Christopher R. Logg,Gerhard A. Coetzee,Nori Kasahara,Baruch Frenkel +5 more
TL;DR: In this paper, glucocorticoids induce premature attenuation of the osteoblast cell cycle, possibly contributing to the osteoporosis induced by these drugs in vivo, but not earlier stages, results in reduction of cyclin A and CDK2 levels with a parallel decrease in the associated kinase activity.
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Bone morphogenetic protein-2 restores mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures.
TL;DR: The anti‐glucocorticoid potential of BMP‐2 in osteoblasts was tested in MC3T3‐E1 cells using dexamethasone (1 μM) and rhB MP‐2 (10 or 100 ng/ml).
Journal ArticleDOI
Gene expression profiling of glucocorticoid-inhibited osteoblasts
Nathalie Leclerc,Cynthia A. Luppen,Vincent V. Ho,Shailender Nagpal,Joseph G. Hacia,Elisheva Smith,Baruch Frenkel +6 more
TL;DR: Microarray-based gene expression analysis of GC-arrested MC3T3-E1 cultures reveals novel gene targets whose regulation by GCs in osteoblasts may shed light on and provide new therapeutic approaches to osteoporosis.