J
Joseph G. Hacia
Researcher at University of Southern California
Publications - 73
Citations - 5033
Joseph G. Hacia is an academic researcher from University of Southern California. The author has contributed to research in topics: Gene expression & Gene expression profiling. The author has an hindex of 36, co-authored 69 publications receiving 4797 citations. Previous affiliations of Joseph G. Hacia include California Institute of Technology & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis.
TL;DR: Fourteen of fifteen patient samples with known mutations were accurately diagnosed, and no false positive mutations were identified in 20 control samples, suggesting DNA chip–based assays may provide a valuable new technology for high–throughput cost–efficient detection of genetic alterations.
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Resequencing and mutational analysis using oligonucleotide microarrays
TL;DR: Current strategies and uses for DNA chip-based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip–based assays are reviewed.
Journal ArticleDOI
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays
Joseph G. Hacia,Jian-Bing Fan,Oliver A. Ryder,Li Jin,Li Jin,Keith Edgemon,G. Ghandour,R. A. Mayer,Bryan K. Sun,Linda Hsie,Christiane M. Robbins,Lawrence C. Brody,David G. Wang,Eric S. Lander,Robert J. Lipshutz,Stephen P. A. Fodor,Frank H. Collins +16 more
TL;DR: In a diverse human population set, it was found that SNP alleles with higher frequencies were more likely to be ancestral than less frequently occurring alleles.
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Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines.
Nancy Braverman,Gerald V. Raymond,William B. Rizzo,Ann B. Moser,Mark E. Wilkinson,Edwin M. Stone,Steven J. Steinberg,Michael F. Wangler,Eric T. Rush,Joseph G. Hacia,Mousumi Bose +10 more
TL;DR: Current clinical approaches for the diagnosis of peroxisome biogenesis disorders in the Zellweger spectrum are provided and broad guidelines for the treatment of disease in its wide variety of forms are provided.
Journal ArticleDOI
Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma
Timothy C. Greiner,Chiranjib Dasgupta,Vincent V. Ho,Dennis D. Weisenburger,Lynette M. Smith,James C. Lynch,Julie M. Vose,Kai Fu,James O. Armitage,Rita M. Braziel,Elias Campo,Jan Delabie,Randy D. Gascoyne,Elaine S. Jaffe,Hans K. Müller-Hermelink,German Ott,Andreas Rosenwald,Louis M. Staudt,Michael Y. Im,Mazen W. Karaman,Brian L. Pike,Wing C. Chan,Joseph G. Hacia +22 more
TL;DR: The molecular signatures are different between cases with mutations and deletions, because the latter are characterized by loss of genes colocalized in the same chromosome region of ATM or p53.