E
Elizabeth J. Hong
Researcher at Harvard University
Publications - 15
Citations - 2530
Elizabeth J. Hong is an academic researcher from Harvard University. The author has contributed to research in topics: Brain-derived neurotrophic factor & Olfactory system. The author has an hindex of 10, co-authored 10 publications receiving 2292 citations. Previous affiliations of Elizabeth J. Hong include Boston Children's Hospital.
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Journal ArticleDOI
Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation
Zhaolan Zhou,Zhaolan Zhou,Elizabeth J. Hong,Elizabeth J. Hong,Sonia Cohen,Sonia Cohen,Wen-Ning Zhao,Hsin-Yi Henry Ho,Hsin-Yi Henry Ho,Lauren Schmidt,Wen G. Chen,Wen G. Chen,Yingxi Lin,Yingxi Lin,Erin M. Savner,Eric C. Griffith,Eric C. Griffith,Linda Hu,Judith A. Steen,Charles J. Weitz,Michael E. Greenberg,Michael E. Greenberg +21 more
TL;DR: It is shown that neuronal activity and subsequent calcium influx trigger the de novo phosphorylation of MeCP2 at serine 421 (S421) by a CaMKII-dependent mechanism, which controls the ability of Me CP2 to regulate dendritic patterning, spine morphogenesis, and the activity-dependent induction of Bdnf transcription.
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Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection
Steven W. Flavell,Tae Kyung Kim,Jesse M. Gray,David A. Harmin,David A. Harmin,Martin Hemberg,Elizabeth J. Hong,Eirene Markenscoff-Papadimitriou,Daniel M. Bear,Michael E. Greenberg +9 more
TL;DR: The characterized genetic program that is activated by MEF2, a key regulator of activity-dependent synapse development, is characterized and it is suggested that the ubiquitously expressed transcription factor MEf2 regulates an intricate transcriptional program in neurons that controls synapses development.
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A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition
Elizabeth J. Hong,Alejandra E. McCord,Alejandra E. McCord,Michael E. Greenberg,Michael E. Greenberg +4 more
TL;DR: A specific requirement for activity-dependent Bdnf expression in the development of inhibition in the cortex is indicated and it is demonstrated that the activation of gene expression in response to experience-driven neuronal activity has important biological consequences in the nervous system.
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Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome
TL;DR: It is found that mutant neurons express significantly lower levels of BDNF than wild-type cells in vitro, as in vivo, under both depolarizing and nondepolarizing conditions, and raise the possibility that ampakine compounds could be of therapeutic value in the treatment of RTT.
Journal ArticleDOI
Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration.
Karun K. Singh,Katya J. Park,Elizabeth J. Hong,Elizabeth J. Hong,Bianca Kramer,Michael E. Greenberg,Michael E. Greenberg,David L. Kaplan,Freda D. Miller +8 more
TL;DR: A mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause their degeneration and, ultimately, axon pruning is described.