Z
Zhaolan Zhou
Researcher at University of Pennsylvania
Publications - 50
Citations - 5295
Zhaolan Zhou is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: MECP2 & Rett syndrome. The author has an hindex of 28, co-authored 50 publications receiving 4716 citations. Previous affiliations of Zhaolan Zhou include Children's Hospital of Philadelphia & Boston Children's Hospital.
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Journal ArticleDOI
Comprehensive proteomic analysis of the human spliceosome.
TL;DR: The spliceosome is identified as the most complex cellular machine so far characterized, containing at least 30 proteins with known or putative roles in gene expression steps other than splicing, and its components comprise all previously known splicing factors and 58 newly identified components.
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Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation
Zhaolan Zhou,Zhaolan Zhou,Elizabeth J. Hong,Elizabeth J. Hong,Sonia Cohen,Sonia Cohen,Wen-Ning Zhao,Hsin-Yi Henry Ho,Hsin-Yi Henry Ho,Lauren Schmidt,Wen G. Chen,Wen G. Chen,Yingxi Lin,Yingxi Lin,Erin M. Savner,Eric C. Griffith,Eric C. Griffith,Linda Hu,Judith A. Steen,Charles J. Weitz,Michael E. Greenberg,Michael E. Greenberg +21 more
TL;DR: It is shown that neuronal activity and subsequent calcium influx trigger the de novo phosphorylation of MeCP2 at serine 421 (S421) by a CaMKII-dependent mechanism, which controls the ability of Me CP2 to regulate dendritic patterning, spine morphogenesis, and the activity-dependent induction of Bdnf transcription.
Journal ArticleDOI
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
TL;DR: It is shown that Aly, the metazoan homologue of the yeast mRNA export factor Yra1p, is recruited to messenger ribonucleoprotein (mRNP) complexes generated by splicing.
Journal ArticleDOI
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly
Ming-juan Luo,Zhaolan Zhou,Keith Magni,Claudine Christoforides,Juri Rappsilber,Matthias Mann,Robin Reed +6 more
TL;DR: It is shown that the conserved DEAD-box helicase UAP56, which functions during spliceosome assembly, interacts directly and highly specifically with Aly and is present together with Aly in the spliced mRNP.
Journal ArticleDOI
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function
Sonia Cohen,Harrison W. Gabel,Martin Hemberg,Ashley N. Hutchinson,L. Amanda Sadacca,Daniel H. Ebert,David A. Harmin,Rachel S. Greenberg,Vanessa K. Verdine,Zhaolan Zhou,William C. Wetsel,Anne E. West,Michael E. Greenberg +12 more
TL;DR: It is shown here that disruption of MeCP2 S421 phosphorylation in vivo results in defects in synapse development and behavior, implicating activity-dependent regulation of Me CP2 in brain development and RTT.