E
Elizabeth M. Mandel
Researcher at University of North Carolina at Chapel Hill
Publications - 4
Citations - 2711
Elizabeth M. Mandel is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Xenopus & Gene silencing. The author has an hindex of 4, co-authored 4 publications receiving 2516 citations.
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Journal ArticleDOI
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Jian-Fu Chen,Elizabeth M. Mandel,J. Michael Thomson,Qiulian Wu,Thomas E. Callis,Scott M. Hammond,Frank L. Conlon,Da-Zhi Wang +7 more
TL;DR: The results show that two mature miRNAs, derived from the same miRNA polycistron and transcribed together, can carry out distinct biological functions and suggest a molecular mechanism in which miRN as participate in transcriptional circuits that control skeletal muscle gene expression and embryonic development.
Journal ArticleDOI
The BMP pathway acts to directly regulate Tbx20 in the developing heart
Elizabeth M. Mandel,Erin Kaltenbrun,Thomas E. Callis,Xin-Xin I. Zeng,Sara R. Marques,Deborah Yelon,Da-Zhi Wang,Frank L. Conlon +7 more
TL;DR: Tbx20 is defined as a direct transcriptional target of the BMP/SMAD1 signaling pathway during cardiac maturation as well as a set of novel, non-canonical, high-affinity SMAD-binding sites located within this regulatory element.
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Developmental expression patterns of Tbx1, Tbx2, Tbx5, and Tbx20 in Xenopus tropicalis†
TL;DR: The identification, sequence analysis, and developmental expression patterns of four members of the T‐box gene family in the diploid frog Xenopus tropicalis are reported, highlighting the high degree of evolutionary conservation between orthologs of these genes in X. tropicalis and other vertebrates.
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Transcriptional mechanisms of congenital heart disease
TL;DR: This review of familial heart diseases linked to cardiac transcription factors and some of the emerging technologies being developed as potential therapeutics for these diseases are described.