D
Deborah Yelon
Researcher at University of California, San Diego
Publications - 99
Citations - 8436
Deborah Yelon is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Zebrafish & Heart formation. The author has an hindex of 46, co-authored 97 publications receiving 7717 citations. Previous affiliations of Deborah Yelon include New York University & Harvard University.
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Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish.
TL;DR: Examination of expression patterns of two zebrafish cardiac myosin genes allow us to distinguish two populations of myocardial precursors at an early stage, well before the heart tube forms and suggest new models for the mechanisms that regulate the formation of a patterned heart tube.
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Gata5 is required for the development of the heart and endoderm in zebrafish
Jeremy F. Reiter,Jonathan Alexander,Adam Rodaway,Deborah Yelon,Roger Patient,Nigel Holder,Didier Y.R. Stainier +6 more
TL;DR: Together, these results implicate zebrafish Gata5 in controlling the growth, morphogenesis, and differentiation of the heart and endoderm and indicate that gata5 regulates the expression of the early myocardial gene nkx2.5.
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Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
TL;DR: It is shown that, in T cells, the mammalian Ras-related GTPase CDC42 can regulate the polarization of both actin and microtubules toward antigen-presenting cells but is not involved in other T-cell signaling processes such as those which culminate in interleukin 2 production.
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The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion
Jinhu Wang,Daniela Panáková,Kazu Kikuchi,Jennifer E. Holdway,Matthew Gemberling,James S. Burris,Sumeet Pal Singh,Amy L. Dickson,Yi-Fan Lin,M. Khaled Sabeh,Andreas A. Werdich,Deborah Yelon,Calum A. MacRae,Kenneth D. Poss +13 more
TL;DR: It is indicated that genetic depletion of cardiomyocytes, even at levels so extreme as to elicit signs of cardiac failure, can be reversed by natural regenerative capacity in lower vertebrates such as zebrafish.
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The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development
Deborah Yelon,Baruch S. Ticho,Marnie E. Halpern,Ilya Ruvinsky,Robert K. Ho,Lee M. Silver,Didier Y.R. Stainier +6 more
TL;DR: These studies reveal early functions for Hand2 in several cellular processes and highlight a genetic parallel between heart and forelimb development.