S
Scott M. Hammond
Researcher at University of North Carolina at Chapel Hill
Publications - 54
Citations - 19556
Scott M. Hammond is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 36, co-authored 51 publications receiving 18289 citations. Previous affiliations of Scott M. Hammond include Watson School of Biological Sciences.
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Journal ArticleDOI
A microRNA polycistron as a potential human oncogene
Lin He,J. Michael Thomson,Michael T. Hemann,Eva Hernando-Monge,David Mu,Summer G. Goodson,Scott Powers,Carlos Cordon-Cardo,Scott W. Lowe,Gregory J. Hannon,Scott M. Hammond +10 more
TL;DR: It is found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in human B-cell lymphomas, and the cluster is implicate as a potential human oncogene.
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Argonaute2 Is the Catalytic Engine of Mammalian RNAi
Jidong Liu,Michelle A. Carmell,Michelle A. Carmell,Fabiola V. Rivas,Carolyn G. Marsden,J. Michael Thomson,Ji-Joon Song,Scott M. Hammond,Leemor Joshua-Tor,Gregory J. Hannon +9 more
TL;DR: The evidence supports a model in which Argonaute contributes “Slicer” activity to RISC, providing the catalytic engine for RNAi.
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The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Jian-Fu Chen,Elizabeth M. Mandel,J. Michael Thomson,Qiulian Wu,Thomas E. Callis,Scott M. Hammond,Frank L. Conlon,Da-Zhi Wang +7 more
TL;DR: The results show that two mature miRNAs, derived from the same miRNA polycistron and transcribed together, can carry out distinct biological functions and suggest a molecular mechanism in which miRN as participate in transcriptional circuits that control skeletal muscle gene expression and embryonic development.
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MicroRNAs Regulate Brain Morphogenesis in Zebrafish
Antonio J. Giraldez,Ryan M. Cinalli,Margaret E. Glasner,Anton J. Enright,J. Michael Thomson,Scott Baskerville,Scott M. Hammond,David P. Bartel,Alexander F. Schier +8 more
TL;DR: Injection of miR-430 miRNAs rescues the brain defects in MZdicer mutants, revealing essential roles for miRNas during morphogenesis.
Journal ArticleDOI
An overview of microRNAs
TL;DR: An overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches is presented, including clinical diagnostics and therapeutic targets.