Elizabeth M. McDowell

TL;DR: In this paper, the histogenesis of epidermoid metaplasia and restoration of normal mucociliary epithelium following mechanical injury was studied in hamster tracheal epithelial cells with single pulse or continuous infusion of tritiated thymidine (3HTdR) combined with colchicine blockade of metaphase mitoses.

TL;DR: The conclusion is that epidermoid metaplasia and carcinoma in situ can result from conversion of mucous cells, which implies the direct transformation of one type of fully differentiated cell to another.

TL;DR: The development of necrosis in the pars recta appears to be a relatively late event, possibly due to further accumulation of Hg++ in this region, and the necrosis appears pathogenetically dissociable from the mechanism of acute renal failure.

TL;DR: Six morphologic cell types comprise the human bronchial epithelium: basal cells that do not reach the bronchia, neurosecretory cells (Kulchitsky's cells, K-cells, or small granule cells) that rarely reach the lumen, and indifferent cells, mucous cells [small mucous granules cells (SMGC) and mucous goblet cells], ciliated cells, and ciliated-mucous cells that does reach theL

TL;DR: These data provide further evidence for the important role of secretory cells in the histogenesis of epidermoid metaplasia and the regeneration of normal morphology following injury in hamster tracheobronchial epithelium.