E
Elke Leupolt
Researcher at University of Ulm
Publications - 8
Citations - 3717
Elke Leupolt is an academic researcher from University of Ulm. The author has contributed to research in topics: Fluorescence in situ hybridization & Mantle cell lymphoma. The author has an hindex of 8, co-authored 8 publications receiving 3553 citations.
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Journal ArticleDOI
Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia
Hartmut Döhner,Stephan Stilgenbauer,Axel Benner,Elke Leupolt,Alexander Kröber,Lars Bullinger,Konstanze Döhner,Martin Bentz,Peter Lichter +8 more
TL;DR: Genomic aberrations in chronic lymphocytic leukemia are important independent predictors of disease progression and survival and have implications for the design of risk-adapted treatment strategies.
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Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival
Stephan Stilgenbauer,Sandrine Sander,Lars Bullinger,Axel Benner,Elke Leupolt,Dirk Winkler,Alexander Kröber,Dirk Kienle,Peter Lichter,Hartmut Döhner +9 more
TL;DR: In vivo resistance to chemotherapy of CLL clones with del(17p13) emphasizes the need for alternative treatment approaches in these patients, and clonal evolution only occurred in CLL with unmutated VH indicating to karyotypic instability as a pathomechanism.
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Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes
Christian Korz,Armin Pscherer,Axel Benner,Daniel Mertens,Claudia Schaffner,Elke Leupolt,Hartmut Döhner,Stephan Stilgenbauer,Peter Lichter +8 more
TL;DR: Overexpression in these malignancies suggests ETV5 as a new candidate for a pathogenic factor in B-cell lymphomas and the combination of CCND1 and CDK4 as the best classifier concerning separation of both lymphoma types is revealed.
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Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma
Stephan Stilgenbauer,Dirk Winkler,German Ott,Claudia Schaffner,Elke Leupolt,Martin Bentz,Peter Möller,Hans K. Müller-Hermelink,Michael R. James,Peter Lichter,Hartmut Döhner +10 more
TL;DR: The identification of a minimally deleted segment affecting ATM suggests a pathogenic role of ATM as a tumor suppressor gene in MCL.
Journal ArticleDOI
Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations
Sandrine Sander,Lars Bullinger,Elke Leupolt,Axel Benner,Dirk Kienle,Tiemo Katzenberger,Jörg Kalla,German Ott,Hans Konrad Müller-Hermelink,Thomas F. E. Barth,Peter Möller,Peter Lichter,Hartmut Döhner,Stephan Stilgenbauer +13 more
TL;DR: The comprehensive analysis of additional genomic aberrations in mantle cell lymphoma provided further evidence for the prognostic relevance of loss of 13q14, which warrants evaluation within prospective trials.