M
Markus H. Kuehn
Researcher at University of Iowa
Publications - 108
Citations - 5519
Markus H. Kuehn is an academic researcher from University of Iowa. The author has contributed to research in topics: Glaucoma & Retina. The author has an hindex of 35, co-authored 103 publications receiving 4675 citations. Previous affiliations of Markus H. Kuehn include University of Pittsburgh & United States Department of Veterans Affairs.
Papers
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Journal ArticleDOI
Primary open-angle glaucoma.
TL;DR: A typical case of glaucoma is presented, together with the ocular findings, and the clinical features, genetics, molecular biology, and cell biology of glAUcoma are discussed.
Journal ArticleDOI
Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus.
Elliott H. Sohn,Hille W. van Dijk,Chunhua Jiao,Pauline H. B. Kok,Woojin Jeong,Nazli Demirkaya,Allison Garmager,Ferdinand W. N. M. Wit,Murat Kucukevcilioglu,Mirjam E J van Velthoven,J. Hans DeVries,Robert F. Mullins,Markus H. Kuehn,Reinier O. Schlingemann,Milan Sonka,Frank D. Verbraak,Michael D. Abràmoff +16 more
TL;DR: This longitudinal study in people with diabetes with no or minimal DR shows thatRDN precedes signs of microvasculopathy and that RDN is progressive and independent of glycated hemoglobin, age, and sex and represents a paradigm shift in the understanding of ocular diabetic complications.
Journal ArticleDOI
Missense variations in the fibulin 5 gene and age-related macular degeneration.
Edwin M. Stone,Terry A. Braun,Stephen R. Russell,Markus H. Kuehn,Andrew J. Lotery,Paula A. Moore,C.G. Eastman,Thomas L. Casavant,Val C. Sheffield +8 more
TL;DR: Seven of the 402 patients with AMD had amino acid-altering sequence variations in the fibulin 5 gene, whereas none were observed among 429 control subjects, which suggests that several of these variations may also be involved in AMD.
Journal ArticleDOI
Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F
Kumar N. Alagramam,Huijun Yuan,Markus H. Kuehn,Crystal L. Murcia,Sigrid Wayne,C. R. Srikumari Srisailpathy,R. Brian Lowry,Russell Knaus,Lut Van Laer,Francois P. Bernier,Stuart Schwartz,Charles Lee,Cynthia C. Morton,Robert F. Mullins,Arabandi Ramesh,Guy Van Camp,Gregory S. Hagemen,Richard P. Woychik,Richard J.H. Smith +18 more
TL;DR: It is shown that protocadherins are essential for maintenance of normal retinal and cochlear function and are found in the linkage interval defined by the USH1F locus.
Journal ArticleDOI
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
Gulab Zode,Markus H. Kuehn,Darryl Y. Nishimura,Charles Searby,Kabhilan Mohan,Sinisa D. Grozdanic,Kevin Bugge,Michael G. Anderson,Abbot F. Clark,Edwin M. Stone,Val C. Sheffield +10 more
TL;DR: Reduction of ER stress with a chemical chaperone, phenylbutyric acid (PBA), prevented glaucoma phenotypes in Tg-MYOC(Y437H) mice by promoting the secretion of mutant myocilin in the aqueous humor and by decreasing intracellular accumulation of myociles in the ER, thus preventing TM cell death.