E
Elliott Middleton
Researcher at University at Buffalo
Publications - 82
Citations - 9284
Elliott Middleton is an academic researcher from University at Buffalo. The author has contributed to research in topics: Histamine & Quercetin. The author has an hindex of 33, co-authored 82 publications receiving 9008 citations. Previous affiliations of Elliott Middleton include Upjohn.
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Journal Article
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Book ChapterDOI
Effect of plant flavonoids on immune and inflammatory cell function
TL;DR: A considerable body of evidence suggests that plant flavonoids may be health-promoting, disease-preventing dietary compounds.
Journal ArticleDOI
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships.
TL;DR: Analysis of structure-activity data revealed a model of the minimal essential features required for PKC inhibition by flavonoids: a coplanar flavone structure with free hydroxyl substituents at the 3', 4' and 7-positions.
Book ChapterDOI
Free Radical Scavenging and Antioxidant Activity of Plant Flavonoids
TL;DR: Their increased production seems to accompany most forms of tissue injury, and the formation of free radicals has been implicated in a multitude of disease states ranging from inflammatory/immune injury to myocardial infarction and cancer.
Journal ArticleDOI
Antitproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro
TL;DR: The polymethoxylated flavonoids, nobiletin and tangeretin, markedly inhibited cell growth at all concentrations tested on days 5 and 7, whereas quercetin and taxifolin exhibited no significant inhibition at any of the concentrations tested.