Showing papers by "Elphège P. Nora published in 2015"
TL;DR: Findings reveal that Mel18 is required to specify PRC1 function in both a context- and stage-specific manner, and reveals an unexpected function of Mel18 in gene activation during cardiac differentiation.
127 citations
TL;DR: The interplay between cardiac transcription factors, cis-regulatory elements, and chromatin as dynamic regulatory networks are discussed, to orchestrate sequential deployment of the cardiac gene expression program.
Abstract: Transcriptional regulation of thousands of genes instructs complex morphogenetic and molecular events for heart development. Cardiac transcription factors choreograph gene expression at each stage of differentiation by interacting with cofactors, including chromatin-modifying enzymes, and by binding to a constellation of regulatory DNA elements. Here, we present salient examples relevant to cardiovascular development and heart disease, and review techniques that can sharpen our understanding of cardiovascular biology. We discuss the interplay between cardiac transcription factors, cis-regulatory elements, and chromatin as dynamic regulatory networks, to orchestrate sequential deployment of the cardiac gene expression program.
76 citations