E
Emanuela Di Salle
Researcher at University of Brescia
Publications - 9
Citations - 387
Emanuela Di Salle is an academic researcher from University of Brescia. The author has contributed to research in topics: Angiogenesis & Fibroblast growth factor. The author has an hindex of 8, co-authored 9 publications receiving 328 citations.
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Journal ArticleDOI
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy
Roberto Ronca,Arianna Giacomini,Emanuela Di Salle,Daniela Coltrini,Katiuscia Pagano,Laura Ragona,Sara Matarazzo,Sara Rezzola,Daniele Maiolo,Rubben Torella,Elisabetta Moroni,Roberta Mazzieri,Giulia Escobar,Marco Mor,Giorgio Colombo,Marco Presta +15 more
TL;DR: Using pharmacophore modeling of the interaction of a minimal PTX3-derived FGF-binding pentapeptide with FGF2, a small-molecule chemical (NSC12) that acts as an extracellular FGF trap with significant implications in cancer therapy is identified.
Journal ArticleDOI
Long Pentraxin-3 Inhibits Epithelial–Mesenchymal Transition in Melanoma Cells
Roberto Ronca,Emanuela Di Salle,Arianna Giacomini,Daria Leali,Patrizia Alessi,Daniela Coltrini,Cosetta Ravelli,Sara Matarazzo,Domenico Ribatti,William Vermi,Marco Presta +10 more
TL;DR: First experimental evidence about a nonredundant role of the FGF/FGFR system in the modulation of the EMT process in melanoma is presented, indicating that PTX3 or its derivatives may represent the basis for the design of novel therapeutic approaches in FGF-FGFR-dependent tumors, including melanoma.
Journal ArticleDOI
Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer.
Roberto Ronca,Patrizia Alessi,Daniela Coltrini,Emanuela Di Salle,Arianna Giacomini,Daria Leali,Michela Corsini,Mirella Belleri,Chiara Tobia,Cecilia Garlanda,Elisa Bonomi,Regina Tardanico,William Vermi,William Vermi,Marco Presta +14 more
TL;DR: PTX3 is identified as a potent FGF antagonist endowed with anti‐angiogenic and anti‐neoplastic activity in prostate cancer.
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Long Pentraxin 3/Tumor Necrosis Factor-Stimulated Gene-6 Interaction: A Biological Rheostat for Fibroblast Growth Factor 2–Mediated Angiogenesis
Daria Leali,Antonio Inforzato,Roberto Ronca,Roberta Bianchi,Mirella Belleri,Daniela Coltrini,Emanuela Di Salle,Marina Sironi,Giuseppe Danilo Norata,Barbara Bottazzi,Cecilia Garlanda,Anthony J. Day,Marco Presta +12 more
TL;DR: In this article, the effect of TSG-6 on PTX3/FGF2 interaction and FGF2-mediated angiogenesis was investigated in vitro and in vivo.
Journal ArticleDOI
Matrigel plug assay: evaluation of the angiogenic response by reverse transcription-quantitative PCR
Daniela Coltrini,Emanuela Di Salle,Roberto Ronca,Mirella Belleri,Chiara Testini,Chiara Testini,Marco Presta +6 more
TL;DR: A simple, rapid, unbiased and reverse transcription-quantitative PCR method to investigate the angiogenic process occurring in the Matrigel plug in response to fibroblast growth factor-2 (FGF2) and consents the quantitative assessment of the effect of local or systemic administration of anti-angiogenic compounds on the neovascular response triggered by FGF2.