R
Roberta Mazzieri
Researcher at University of Queensland
Publications - 60
Citations - 5988
Roberta Mazzieri is an academic researcher from University of Queensland. The author has contributed to research in topics: Urokinase receptor & Cancer. The author has an hindex of 27, co-authored 57 publications receiving 5344 citations. Previous affiliations of Roberta Mazzieri include Translational Research Institute & Vita-Salute San Raffaele University.
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Journal ArticleDOI
Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells
Roberta Mazzieri,Ferdinando Pucci,Davide Moi,Erika Zonari,Anna Ranghetti,Alvise Berti,Letterio S. Politi,Bernhard Gentner,Jeffrey L. Brown,Luigi Naldini,Michele De Palma +10 more
TL;DR: Blocking angiopoietin-2 (ANG2), a TIE2 ligand and angiogenic factor expressed by activated endothelial cells (ECs), regresses the tumor vasculature and inhibits progression of late-stage, metastatic MMTV-PyMT mammary carcinomas and RIP1-Tag2 pancreatic insulinomas.
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Latent transforming growth factor-β: Structural features and mechanisms of activation
John S. Munger,John G. Harpel,Pierre-Emmanuel Gleizes,Roberta Mazzieri,Irene Nunes,Daniel B. Rifkin +5 more
TL;DR: A general model of activation is proposed in which latent TGF-beta is released from the extracellular matrix by proteases, localized to cell surfaces, and activated by cell-associated plasmin.
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Targeted genome editing in human repopulating haematopoietic stem cells
Pietro Genovese,Giulia Schiroli,Giulia Escobar,Tiziano Di Tomaso,Claudia Firrito,Andrea Calabria,Davide Moi,Roberta Mazzieri,Chiara Bonini,Michael C. Holmes,Philip D. Gregory,Mirjam van der Burg,Bernhard Gentner,Eugenio Montini,Angelo Lombardo,Luigi Naldini +15 more
TL;DR: Gene-edited HSCs sustained normal haematopoiesis and gave rise to functional lymphoid cells that possess a selective growth advantage over those carrying disruptive IL2RG mutations, which opens up new avenues for treating SCID-X1 and other diseases.
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Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein
Zenzo Isogai,Robert N. Ono,Shin Ushiro,Douglas R. Keene,Yan Chen,Roberta Mazzieri,Noe L. Charbonneau,Dieter P. Reinhardt,Daniel B. Rifkin,Lynn Y. Sakai +9 more
TL;DR: Immunolocalization data were consistent with the hypothesis that LTBP-1 is a fibrillin-associated protein present in certain tissues but not in others, and a model depicting the relationship between LT BP-1 and fibrillins microfibrils is proposed.
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Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.
Mary Anna Venneri,Michele De Palma,Maurilio Ponzoni,Ferdinando Pucci,Cristina Scielzo,Erika Zonari,Roberta Mazzieri,Claudio Doglioni,Luigi Naldini +8 more
TL;DR: It is reported that TIE2 expression in human blood identifies a subset of monocytes distinct from classical inflammatory monocytes and comprised within the less abundant "resident" population of blood monocytes, suggesting a potentially critical role of TEMs in human cancer progression.