Emanuele Mazzola

TL;DR: Analysis of serial samples from individual patients revealed that the presence of a mutation in SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, or STAG2 was >95% specific for the diagnosis of s-AML and highlights a subset of patients with worse clinical outcomes, including a lower complete remission rate, more frequent reinduction, and decreased event-free survival.

TL;DR: It is found that staple placement at the amphipathic boundary combined with optimal hydrophobic and helical content are the key drivers of cellular uptake, whereas excess hydrophobicity and positive charge at isolated amino acid positions can trigger membrane lysis at elevated peptide dosing.

TL;DR: The majority of existing breast cancer risk prediction models are summarized, including the risk factors they incorporate, the basic methodology in their development, the information each provides, their strengths and limitations, relevant validation studies, and how to access each for clinical or investigative purposes are summarized.

TL;DR: Physicians should counsel patients with atypical ductal hyperplasia, ALH, LCIS, and severe ADH about the benefit of chemoprevention in decreasing their breast cancer risk.

TL;DR: A serum-based molecular predictor identifies asymptomatic pregnant women atrisk of spontaneous preterm delivery, which may provide utility in identifying women at risk at an early stage of pregnancy to allow for clinical intervention.